合聘師資-中央大學生命科學系資訊網

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系所成員

合聘師資

  • 發佈日期: 2021-08-01
  • 最後更新日: 2022-08-16
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莊宗顯 博士

簡介與授課

‧ 個人資訊:http://im.nhri.org.tw/index.php/dr-tsung-hsien-chuang/


‧ 學歷:
1.  Iowa State University Department of Biochemistry, Biophysics and Molecular Biology Molecular, Cellular and Developmental Biology Interdepartmental Graduate Program 博士1986-1992

2.  National Chiao Tung University Department of Applied Chemistry 碩士1982-1984

3.  National Changhua University of Education Department of Chemistry 學士(1976-1980

‧ 經歷:

1.  Investigator, Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli County(2017-present)
2.   Associate Investigator, Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli County(2010- 2017
3.   Associate Investigator, Burnham Institute for Medical Research (BIMR), La Jolla, CA (SKCC was acquired by BIMR on July 1st, 2009)(2009 -2010
4.   Associate Professor, Sidney Kimmel Cancer Center (SKCC), San Diego, CA(2008-2009
5.   Associate Professor of Immunology, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA(2006-2008
6.   Assistant Professor, Department of Immunology, The Scripps Research Institute, La Jolla, CA(1998-2006
7.   Senior Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, CA(1995-1998
8.   Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, CA(1992-1995
9.   Teaching Assistant and Research Assistant, Iowa State University, Ames, IA(1986-1992
10.   Associate Research Scientist, Material Research Laboratories, Industrial Technique Research Institute, Taiwan(1984-1986
11.   Military Service, Taiwan(1980-1982

研究領域
論文發表

1. 

Chuang TH, Xu X, Knaus UG, Hart MJ, and Bokoch GM. (1993) GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein. J. Biol. Chem. 268: 775-778.


2. 

Chuang TH, Bohl BJ, and Bokoch GM. (1993) Biologically active lipids are regulators of Rac.GDI complexation. J. Biol. Chem. 268: 26206-26211.


3. 

Chuang TH, Xu X, Quilliam LA and Bokoch GM. (1994) SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism. Biochem. J. 303(3): 761-767.


4. 

Bokoch GM, Bohl BP, and Chuang TH. (1994) Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. J. Biol. Chem. 269: 31674-31679.


5. 

Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, and Bokoch GM. (1995) Abr and Bcr are multifunctional regulators of the Rho GTP binding protein family. Proc. Natl. Acad. Sci. USA. 92:0282-10286.

6. 

Chuang TH, Hamilton RT, and Nilsen-Hamilton M. (1995) Cloning of mink plasminogen activator inhibitor type 1 messenger RNA: a mRNA with a short life. Gene 162: 303-308.

7. 

Danley DE, Chuang TH, and Bokoch GM. (1996) Defective Rho GTPase regulation by IL-1ß converting enzyme mediated cleavage of D4 GDP dissociation inhibitor. J. of Immunol. 157:500-503.


8.

Martin SJ, Amarante-Mendes GP, Tewari M, Shi L, Chuang TH, Casciano C, Fitzgerald P, Tan EM, Bokoch GM, Dixit VM, Greenberg AH, and Green DR. (1996) The cytotoxic cell protease granzyme Binitiates apoptosis by proteolytic processing and activation of the ICE/CED-3-family protesae, cpp32. EMBO J. 15: 775-779.


9. 

Na S, Chuang TH, Cunningham A, Turi TG, Hanke JH, Bokoch GM, and Danley DE. (1996) D4 GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem. 271:11209-11213.


10. 

Lamaze C, Chuang TH, Terlecky LJ, Bokoch GM, and Schmid SL. (1996) Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382: 177-179.


11. 

Chuang TH. Hahn KM. Lee JD, Danley DE, and Bokoch GM. (1997). The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Mol. Biol. Cell. 8, 1687-1698.

12. 

Thomas R, Frank Z, Chuang TH, and Bokoch, GM. (1998) p21-activated kinase 2 (PAK2) induces apoptosis and is required for Fas-induced JNK activation in Jurkat T cells. J. of Immunol. 160: 7-11.

13. 

Subauste MC, Herrath MV, Benard V, Chamberlain C., Chuang TH, Chu K, Bokock GM, and Hahn KM. (2000) Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J. Biol. Chem. 275: 9725-9733.


14. 

Chuang TH, and Ulevitch RJ. (2000) Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Network. 11: 372-378.


15. 

Chuang TH, and Ulevitch RJ. (2000) Identification of hTLR10: A novel human Toll-like receptor preferentially expressed in immune cells. Biochem. Biophys. Acta. 1518: 157-161.

16. 

Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Girons IS, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, and Ulevitch RJ. (2001) Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat. Immunol. 2: 346-352.

17. 

Golovanov AP*, Chuang TH*, DerMardirossian C, Barsukov I, Haekins R, Badii R, Bokoch GM, Lian LY, and Roberts, G.C. (2001) Structure-activity relationships in flexible protein domains: regulation Rho GTPase by Rho GDI and D4GDI. J. Mol. Biol. 305: 121-135. (* equal contribution)


18. 

Chuang TH*, Lee J, Kline L, Mathison JC, and Ulevitch RJ (2002) Toll-like receptor 9 mediates CpG-DNA signaling and distinguishes different CpG motifs and backbones. J. Leuko. Biol. 71, 538-554. (* corresponding author)

19. 

Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, and Cottom HB. (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Tolllike Receptor 7. Proc. Natl. Acad. Sci.USA. 100(11): 6646-51.

20. 

Chuang TH, and Ulevitch RJ. (2004) Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 5(5):495-502.

21. 

Zhang P, Chan J, Dragoi AM, Gong X, Ivanov S, Li ZW, Chuang TH, Tuhill C, Wan Y, Karin M, and Chu WM. (2005) Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. EMBO Rep. 6(6): 531-7.


22. 

Wang T*, Chuang TH*, Ronni T*, Gu S, Du YC, Cai H, Sun HQ, Yin HL, and Chen X.(2006) Flightless I homolog negatively modulates the TLR pathway. J. Immunol.176(3):1355-62. (equal contribution)


23. 

Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottom HB, Lai MM, Raz E, and Carson DA. (2006) Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc. Natl. Acad. Sci. USA. 103(6):1828-33.


24. 

Fearns C, Pan Q, Mathison JC, and Chuang TH. (2006) Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. J Biol Chem. 281(45):34592-600.

25. 

Lee J, Hayashi M, Lo JF, Fearns C, Chu WM, Xiang R, and Chuang TH. (2009) NF-B activation primescells to a pro-inflammatory polarized response to a TLR7 agonist. Biochem. J. 421(2):301-10. (IF=4.779;Journal ranking : 61/291, Biochemistry & Molecular Biology) (通訊作者)


26. 

Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, and Hiscott J.(2009) The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradartion. PLoS Pathog. 5(11):e1000650. (IF=8.057;Journal ranking : 10/119, Microbiology)


27. 

Luo Y, Zhou H, Krueger J, Kaplan C, Liao D, Markowitz D, Liu C, Chen T, Chuang TH, Xiang R, and Reisfeld RA (2010) The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression. Oncogene. 4;29(5):662-73. (IF=8.559;Journal ranking : 12/203 Oncology)


28. 

Liu J, Xu C, Hsu LC, Luo Y, Xiang R, and Chuang TH. (2010) A five amino acids motif at the undefined region of TLR8 ectodomain is required for species-specific recognition of agonists. Mol Immunol. 47(5):1083-1090. (IF=3.003; Journal ranking :66/144, Immunology) (通訊作者)


29. 

Xiang R, Liao D, Cheng T, Zhou H, Shi Q, Chuang TH, Markowitz D, Reisfeld RA, Luo Y. (2011) Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer. 104(9):1410-7. (IF=4.814; Journal ranking :42/203, Oncology)


30. 

Xu C, Liu J, Hsu LC, Luo Y, Xiang R, and Chuang TH. (2011) Functional interaction of Hsp90 and Beclin1 Modulates Toll-like receptors mediated autophagy. FASEB J. 25(8):2700-10. (IF=5.480; Journal ranking :7/85, Biology)


31. 

Chen YS, Wu MJ, Huang CY, Lin SC, Chuang TH, Yu CC, and Lo JF. (2011) CD133/Src Axis Mediates Tumor Initiating Property and Epithelial-Mesenchymal Transition of Head and Neck Cancer. PLoS One. 2011;6(11):e28053. (IF=3.534; Journal ranking :8/55, Multidisciplinary Sciences)

32. 

Liu J, Xu C, Liu YL , Matsuo H, Hsieh RP, Lo JF, Tseng PH, Yuan CJ, Luo Y, Xiang R, and Chuang TH. (2012) Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9. Comp Immunol Microbiol Infect Dis. 35(5):443-51. (IF=2.107; Journal ranking :12/132, Veterinary Sciences) (通訊作者)

33.

Daniel J. Klionsky and 1269 other authors including Chuang TH. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy (2nd Ed). Autophagy. 8(4):445-544.. (Review) (IF=11.423; Journal ranking :15/185, Cell Biology)


34. 

Yang J, Liao D, Chen C, Liu Y, Chuang TH, Xiang R, Markowitz D, Reisfeld RA, and Luo Y.(2012) Tumor associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells. 31(2):248-58. (IF=7.133; Journal ranking : 16/203,Oncology)

35. 

Ho CC, Luo YH, Chuang TH, Yang CS, Ling YC, and Lin P. (2013) Quantum dots induced monocyte chemotactic protein-1 expression via MyD88-dependent Toll-like receptor signaling pathways in macrophages. Toxicology. 308C:1-9. (IF=3.745; Journal ranking :14/87,Toxicology)

36. 

Chuang SY, Yang CH, Chou CC, Chiang YP, Chuang TH, Hsu LC. (2013) TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation. Proc Natl Acad Sci U S A. 110(40):16079-84. (IF=9.809; Journal ranking :4/55, Multidisciplinary sciences)


37. 

Yeh DH, Liu YL, Lo YC, Yuh CH, Yu GY, Lo JF, Luo Y, Xiang R, and Chuang TH (2013) Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpGoligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 110(51):20711-6. (IF=9.809; Journal ranking :4/55, Multidisciplinary sciences) (通訊作者)


38.

Yang J, Zhang Z, Chen C, Liu Y, Si Q, Chuang TH, Li N, Gomez-Cabrero A, Reisfeld RA, Xiang R, Luo Y. (2014) MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene. 33(23):3014-23.. (IF=8.559;Journal ranking : 12/203 Oncology)


39. 

Hsieh MY, Chang MY, Chen YJ, Li YK, Chuang TH, Yu GY, Cheung CH, Chen HC, Maa MC, Leu TH.(2014) The iNOS/Src Axis Mediates Toll-Like Receptor 3 Tyrosine 759 phosphorylation and Enhances Its Signal Transduction Leading to Interferon-β Synthesis in Macrophages. J Biol Chem. 289(13):9208-20. (IF=4.6, Journal ranking :65/291, Biochemistry & Molecular Biology)

40. 

Chuang TH, Lai CY, Tseng PH, Yuan CJ, Hsu LC. (2014) Development of CpG-oligodeoxynucleotides for effective activation of rabbit TLR9 mediated immune responses. PLoS One. 9(9):e108808. (IF=3.534; Journal ranking :8/55, Multidisciplinary Sciences) (第一作者, 通訊作者)


41. 

Lai CY, Liu YL, Yu GY, Maa MC, Leu TH, Xu C, Luo Y, Xiang R, Chuang TH. (2014) TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 32(43):5593-9. (IF=3.485 Journal ranking :35/124, Medicine, Research, and Experimental) (通訊作者)


42. 

Xu C, Feng K, Zhao X, Huang S, Cheng Y, Qian L, Wang Y, Sun H, Jin M, Chuang TH, Zhang Y. (2014) Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination. Autophagy. 10(12):2239-50. (IF=11.423; Journal ranking :15/185, Cell Biology)

43. 

Kuo YL, Chen CH, Chuang TH, Hua WK, Lin WJ, Hsu WH, Chang PM, Hsu SL, Huang TH, Kao CY, Huang CY. (2015) Gene Expression Profiling and Pathway Network Analysis Predicts a Novel Antitumor Function for a Botanical-Derived Drug, PG2. Evid Based Complement Alternat Med. 2015:917345. (IF=2.175 Journal ranking :6/22, Integrative and complementary medicine).

44. 

Chen C, Cao F, Bai L, Liu Y, Xie J, Wang W, Si Q, Yang J, Chang A, Liu D, Liu D, Chuang TH, Xiang R, Luo Y.(2015) IKKβ Enforces a LIN28B/TCF7L2 Positive Feedback Loop That Promotes Cancer Cell Stemness and Metastasis. Cancer Res. 75(8):1725-35. (IF=9.284. Journal ranking :10/203, Oncology).


45. 

Chang A, Chen Y, Shen W, Gao R, Zhou W, Yang S, Liu Y, Luo Y, Chuang TH, Sun P, Liu C, Xiang R. (2015) Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway. J Infect Dis.;212(9):1509-20. (IF=5.997. Journal ranking :4/78, Infectious diseases).


46. 

Lai CY, Yeh DW, Lu CH, Liu YL, Huang LR, Kao CY, Chen HY, Huang CY, Chang CH, Luo Y, Xiang R, Chuang TH. (2015) Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9. J Immunol. 195(8):3912-21. (IF=4.922. Journal ranking :26/148, Immunology) (通訊作者)

47. 

Yeh DW, Chen YS, Lai CY, Liu YL, Lu CH, Lo JF, Chen L, Hsu LC, Luo Y, Xiang R, Chuang TH. (2016) Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells..Cell Death Differ. 23(5):841-52. (IF=8.184. Journal ranking :24/290, Biochemistry and Molecular Biology) (通訊作者)


48. 

Daniel J. Klionsky et. al. including Chuang TH. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3 rd edition). Autophagy. 12(1):1-222. (IF=11.735; Journal ranking :15/184, Cell Biology)

49. 

Tsai MH, Chang CH, Tsai RK, Hong YR, Chuang TH, Fan KT, Peng CW, Hsu WL, Wang LS, Chen LK,Wu CY, Yu HS (2016) Crossregulation of Proinflammatory Cytokines by Interleukin10 and MiR155 in Orientia tsutsugamushiinfected Human Macrophages Prevents Cytokine Storm. J Invest Dermatol. 136(7):1398-407. (IF=7.216. Journal ranking :1/63, Dermatology)


50. 

Ho CC, Luo YH, Chuang TH, Lin P. (2016) Quantum dots induced interferon beta expression via TRIFdependent signaling pathways by promoting endocytosis of TLR4. Toxicology. 17;344-346:61-70. (IF=3.621. Journal ranking :58/255, Pharmacology and Pharmacy)

51. 

Lin KH, Chang LS, Tian CY, Yeh YC, Chen YJ, Chuang TH, Liu SJ, Leng CH.(2016) Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity.Sci Rep. 6:24199. (IF=5.578; Journal ranking :5/57, Multidisciplinary sciences)

52. 

Tsai WT, Lo YC, Wu MS, Li CY, Kuo YP, Lai YH, Tsai Y, Chen KC, Chuang TH, Yao CH, Lee JC, Hsu LC, Hsu JT, Yu GY. (2016) Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy. J Biol Chem. 291(37):19299-311 (IF=4.258; Journal ranking :71/289, Biochemistry and Molecular Biology)


53. 

Yeh DW, Huang LR, Chen YW, Huang CY and Chuang TH (2016) Interplay between inflammation and stemness in cancer cells: The role of Toll-like receptor signaling. J of Imm Res. Article ID 4368101. (Review paper, IF=3.276; Journal ranking: 63/151, Immunology). (通訊作者)


54. 

Yang JX, Hsieh KC, Chen YL, Lee CK, Conti M, Chuang TH, Wu CP, Jin SC. (2017)Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.SciRep. 6;7:46165. doi: 10.1038/srep46165. (IF=4.259; Journal ranking :10/64, Multidisciplinary sciences)

55. 

Jian SL, Chen WW, Su YC, Su YW, Chuang TH, Hsu SC, Huang LR. (2017) Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts throughprevention of ROS-mediated apoptosis. Cell Death Dis. 11;8(5):e2779. (IF=5.965; Journal ranking :39/189, Cell biology)


56. 

Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH. (2017) Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation. J Immunol Res. 2017:7807313. (Review paper, IF=3.298; Journal ranking : 72/155, Immunology). (通訊作者)


57. 

Yeh DW, Lai CY, Liu YL, Lu CH, Tseng PH, Yuh CH, Yu GY, Liu SJ, Leng CH, Chuang TH. (2017) CpGoligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and
human TLR9s mediated immune responses. Sci Rep. 2017 Dec 11;7(1):17297. (IF=4.259; Journal ranking :10/64, Multidisciplinary sciences) (通訊作者)


58. 

Kuo YP, Tsai KN, Luo YC, Chung PJ, Su YW, Teng Y, Wu MS, Lin YF, Lai CY, Chuang TH, Dai SS, Tseng FC, Hsieh CH, Tsai DJ, Tsai WT, Chen CH, Yu GY. (2018) Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus. PLoS Negl Trop Dis. 12(4):e0006417. (IF=3.834; Journal ranking :1/19, Tropical Medicine)

59. 

Lu CH, Yeh DW, Lai CY, Liu YL, Huang LR, Lee AY, Jin SC, Chuang TH.(2018) USP17 mediates macrophagepromoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation. Oncogene. (49):6327-6340. (Correction: 2019 Jul;38(28):5742-5743.) (IF=6.854; Journal ranking :15/171, Genetic and Heredity). (通訊作者)

60. 

Ko YA, Chan YH, Liu CH, Liang JJ, Chuang TH, Hsueh YP, Lin YL, Lin KI. (2018) Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M. Front Immunol.;9:1828. (IF=5.511; Journal ranking :30/155, Immunology).

61. 

Lu CH, Lai CY, Chuang TH (2018) Macrophages promote progression of lung cancer by regulating ubiquitin-specific peptidase 17 in cancer cells. Integr Cancer Sci Therap, 5(5): 1-2. doi:10.15761/ICST.1000290 ( Review, non SCI) (通訊作者)


62. 

Yang JX, Hsiung TC, Weng FC, Ding SL, Wu CP, Conti M, Chuang TH, Jin SL. (2018) Synergisticeffect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. Innate Immun. 24(8):501-512. (IF=2.312; Journal ranking :112/155, Immunology).

63. 

Lu CH, Lai CY, Yeh DW, Liu YL, Su YW, Hsu LC, Chang CH, Jin SC, Chuang TH (2018) Involvement of M1 macrophage polarization in endosomal toll-like receptors activated psoriatic inflammation. Mediators Inflamm. 2018:3523642. (IF=3.549; Journal ranking :61/155, Immunology). (通訊作者)

64. 

Liu YT, Tseng TC, Soong RS, Peng CY, Cheng YH, Huang SF, Chuang TH, Kao JH, Huang LR.(2018)A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment. J Immunother Cancer. 2018 Dec 7;6(1):144. (IF=8.374; Journal ranking :13/155, Immunology).


65. 

Chen MY, Hsu WC, Hsu SC, Yang YS, Chuang TH, Lin WJ, Tan TH, Su YW (2019) PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency. Cell Death and Differ. (7):1221-1234. (IF=8.000. Journal ranking :26/290, Biochemistry and Molecular Biology)

66. 

Lai CY, Yu GY, Luo Y, Xiang R, Chuang TH.(2019) Immunostimulatory Activities of CpGOligodeoxynucleotides in Teleosts: Toll-Like Receptors 9 and 21.Front Immunol. 8;10:179. (Review.). (IF=5.511;Journal ranking :30/155, Immunology).

67.

, Bai L, Cao F, Wang S, He H, Song M, Chen H, Liu Y, Guo J, Si Q, Pan Y, Zhu R, Chuang TH, Xiang R, Luo Y.(2019) Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis. Oncogene. 38(23):4527-4539. (IF=6.854; Journal ranking :15/171, Genetic and Heredity).


68. 

Traisaeng S, Herr DR, Kao HJ, Chuang TH, Huang CM. (2019) A Derivative of Butyric Acid, the Fermentation Metabolite of Staphylococcus epidermidis, Inhibits the Growth of a Staphylococcus aureus Strain Isolated from Atopic Dermatitis Patients. Toxins (Basel). 11(6). pii: E311. (IF=3.273; Journal ranking :25/94, Toxicology)


69. 

Keshari S, Sipayung AD, Hsieh CC, Su LJ, Chiang YR, Chang HC, Yang WC, Chuang TH, Chen CL, Huang CM. (2019) The IL-6/p-BTK/p-ERK signaling mediates the calcium phosphate-induced pruritus. FASEB J. 33(11):12036-12046 (IF=4.966; Journal ranking: 9/93, Biology)

70. 

Chen YL, Liu KJ, Jang CW, Hsu CC, Yen YC, Liu YL, Chuang TH, Wang SH, Fu YK, Kuo CC, Chen YW. (2019) ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line. Cancers (Basel). 12(1). pii: E61. (IF=6.126; Journal ranking :37/244, Oncology).


71. 

Lai CY, Yeh DW, Lu CH, Liu YL, Chuang YC, Ruan JW, Kao CY, Huang LR, Chuang TH. (2020) Epigenetic Silencing of Ubiquitin Specific Protease 4 by Snail1 Contributes to Macrophage-Dependent Inflammation and Therapeutic Resistance in Lung Cancer.Cancers (Basel). 12(1):148. (通訊作者,IF=6.126; Journal ranking :37/244, Oncology).


72. 

Yang JJ, Huang YC, Chuang TH, Herr DR, Hsieh MF, Huang CJ, Huang CM. (2020) Cysteine-Capped Hydrogels Incorporating Copper as Effective Antimicrobial Materials against Methicillin-Resistant Staphylococcus aureus. Microorganisms. 8(2). pii: E149. (IF=4.152; Journal ranking :37/134, Microbiology).


73. 

Keshari S, Wang Y, Herr DR, Wang SM, Yang WC, Chuang TH, Chen CL, Huang CM. (2020) Skin Cutibacterium acnes Mediates Fermentation to Suppress the Calcium Phosphate-Induced Itching: A Butyric Acid Derivative with Potential for Uremic Pruritus.J Clin Med. 9(2). pii: E312. (IF=3.303; Journal ranking:36/165, Medicine, general and internal)


74. 

Traisaeng S, Batsukh A, Chuang TH, Herr DR, Huang YF, Chimeddorj B, Huang CM (2020) Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice. Sci Rep. 2020 May 13;10(1):7928. (IF=3.998; Journal ranking: 17/71, Multidisciplinary sciences)


75. 

Chuang YC, Tseng JC, Huang LR, Huang CM, Huang CF, Chuang TH. (2020) Adjuvant Effect of Toll-Like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade. Front Immunol 29;11:1075. (review, 通訊作者, IF=5.085; Journal ranking: 38/158, Immunology)


76. 

Yang JJ, Pham MT, Rahim AR, Chuang TH, Hsieh MF, Huang CM. (2020) Mouse Abdominal Fat Depots Reduced by Butyric Acid-Producing Leuconostoc mesenteroides. Microorganisms. 8(8):E1180. (IF=4.152; Journal ranking :37/134, Microbiology).


77. 

Yang JJ, Rahim AR, Yang AJ, Chuang TH, Huang CM. (2020) Production of electricity and reduction of high-fat diet-induced IL-6 by glucose fermentation of Leuconostoc mesenteroides. Biochem Biophys Res Commun. (20)31857-X. (IF=2.985; Journal ranking:159/297, Biochemistry and molecular biology). 


78. 

Chuang YC, Tseng JC, Yang JX, Liu YL, Yeh DW, Lai CY, Yu GY, Hsu LC, Huang CM, Chuang TH.Toll-Like Receptor 21 of Chicken and Duck Recognize a Broad Array of Immunostimulatory CpG-oligodeoxynucleotide Sequences.Vaccines (Basel). 2020 Nov 2;8(4):E639. (IF=4.086; Journal ranking: 59/159, Immunology).

79. 

Cheng AN, Cheng LC, Kuo CL, Lo YK, Chou HY, Chen CH, Wang YH, Chuang TH, Cheng SJ, Lee AY. (2020) Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1-mediated immunoescape via STING-IFN signaling and extracellular vesicles. J Immunother Cancer. 8(2):e001372. (IF=10.252; Journal ranking:10/159, Immunology)

榮譽事項

專利

1. CpG 寡去氧核苷酸、包含其之免疫組合物及製備組合物並藉其刺激免疫反應的方法
中華民國專利: I545451 (June 1, 2016-July 17, 2034).

2. CpG 寡脫氧核苷酸、包含其之免疫組成物以及以其製備用於誘發免疫反應
之藥物的用途
中華民國專利: I653240 (March 11, 2019-December 17, 2037).


3. CpG-oligodeoxynucleotide, immunogenic composition inducing the same, and method of inducing immune response by the same.
US patent No: 10246715B1 (Date of patent: April 2, 2019 )

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