歷屆系主任-中央大學生命科學系資訊網

STAFF系所成員

首頁系所成員歷屆系主任金秀蓮 博士

系所成員

歷屆系主任

  • 發佈日期: 2020-04-23
  • 最後更新日: 2020-06-01
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  • 瀏覽人次：1354

金秀蓮 博士

  • 職稱: 第八任系主任(96.8~99.7)
  • 學歷: 美國北卡羅萊納大學(教堂山) 生理學博士
  • 專長: 免疫、生理、訊息傳遞、細胞分子生物
  • 信箱: slcj@cc.ncu.edu.tw
  • 分機: 65066
現職與學經歷
  • 現   職：
  1. 國立中央大學 生命科學系 教授
  • 學　歷:
  1. 美國北卡羅萊納大學(教堂山) 生理學博士 (1989)
  2. 美國維吉尼亞理工州立大學 厭氧微生物學碩士 (1983)
  3. 美國北達科塔州立大學 動物學碩士 (1979)
  4. 國立台灣大學 動物系學士 (1976)
  • 經　歷:
  1. 國立中央大學 生命科學系 教授兼系主任 (2007~2010)
  2. 美國史丹佛大學醫學院婦產科 資深研究員 (1998~2006)
  3. 美國史丹佛大學醫學院婦產科 副研究員 (1996~1998)
  4. 美國杜克大學麻醉學 副研究員 (1995~1996)
  5. 美國Glaxo Research Institute, Research Triangle Park, NC分子遺傳學 研究室主持人 (Research Investigator I) (1993~1995)
  6. 美國Glaxo Research Institute, Research Triangle Park, NC分子生物學 資深研究員 (1992~1993)
  7. 美國Glaxo Research Institute, Research Triangle Park, NC藥學部 博士後研究 (1991~1992)
  8. 美國北卡羅萊納大學(教堂山) 小兒科生理學 博士後研究 (1989~1991)
  9. 美國維吉尼亞理工州立大學 厭氧微生物學 研究技術人員 (1979~1980)
  10. 國防醫學院 研究助理 (1976~1977)


授課與研究領域
  • 授   課
    1. 細胞學
    2. 免疫學
    3. 動物生理學
    4. 發炎反應之訊息傳導


  • 研究領域
    環狀核苷酸訊息傳導、發炎疾病機制、抗發炎藥劑研發

  • 研究主題
    1. cAMP訊息傳導對氣喘致病過程的調控
    2. 磷酸雙酯酶PDE4B對氣喘發炎細胞的功能調節
    3. 磷酸雙酯酶PDE4B參與免疫細胞內巨大分子複合體的特性與訊息傳導功能
    4. 類風溼性關節炎致病分子及生物標記之鑑定
    5. 奈米科技應用於幹細胞分化與功能
    6. 利用奈米微粒運送DNA以治療發炎疾病
論文發表

Original papers

  1. Hu WW, Huang SC, Jin S.-L.C. (2019) A novel antimicrobial peptide-derived vehicle for oligodeoxynucleotide delivery to inhibit TNF-α expression. International J. Pharmaceutics 558:63-71. https://doi.org/10.1016/j.ijpharm.2018.12.082 (Mar 2019)
  2. Lu CH, Lai CY, Yeh DW, Liu YL, Su YW, Hsu LC, Chang CH, Jin S.-L.C., Chuang TH* (2018) Involvement of M1 macrophage polarization in endosomal toll-like receptors activated psoriatic inflammation. Mediators of Inflammation, vol. 2018, https://doi.org/10.1155/2018/3523642. (Dec 2018)
  3. Yang JX, Hsiung TC, Weng FC, Ding SL, Wu CP, Conti M, Chuang TH, Jin S.-L.C.* (2018) Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. Innate Immunity 24 (8), doi.org/10.1177/1753425918809155 (Nov 2018)
  4. Lu CH, Yeh DW, Lai CY, Liu YL, Huang LR, Lee AY, Jin S.-L.C., Chuang TH* (2018) USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation. Oncogene, doi: 10.1038/s41388-018-0411-0 (July, 2018)
  5. Yang JX, Hsieh KC, Chen YL, Lee CK, Conti M, Chuang TH, Wu CP, Jin S.-L.C. (2017) Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. Scientific Reports 7:46165. doi:10.1038/srep46165 (Apr 6, 2017)
  6. Peng HY, Cheng YC, Hsu YM, Wu GH, Kuo CC, Liou JP, Chang JY, Jin S.-L.C., Shiah SG (2016) MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma. Plos One 11(7):e0158440. DOI:10.1371/journal.pone.0158440 (July 1, 2016)
  7. Peng HY, Hsiao JR, Hsiao M, Chang WM, Hsu YM, Wu GH, Chang JY, Jin S.-L.C., Shiah SG (2016) IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma. Molecular Oncology 10(6):895-909.
  8. Tsai CW, Hu WW, Liu CI, Ruaan RC, Tsai BC, Jin S.-L.C., Chang Y, Chen WY (2015) The consideration of indolicidin modification to balance its hemocompatibility and delivery efficiency. International J. Pharmaceutics 494(1):498-505.
  9. Lai CR, Lo HC, Chen YL, Yang JX, Ding SL, Hsu HH, Conti M, Wu CP, Jin S.-L.C. (2015) Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages. J. Med. Sci. 35(3):111-121
  10. Lu, JW, Liao CY, Yang WY, Lin YM, Jin S.-L.C, Wang, HD, and Yuh CH. (2014) Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. Plos One 9(1):e85318.
  11. Hu WW, Lin ZW, Ruaan RC, Chen WY, Jin S.-L.C., Chang Y. (2013) A novel application of indolicidin for gene delivery. International J. Pharmaceutics 456:293-300.
  12. Lu, JW, Yang WY, Lin YM, Chang PH, Chen JR, Tsai SM, Wu JL, Jin S.-L.C., Wang, HD, and Yuh CH. (2013) Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. Plos One 8(10):e76951.
  13. Lu JW, Yang WY, Lin YM, Jin S.-L.C., and Yuh CH. (2013) Hepatitis B virus X antigen and Aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta Histochem. 115(7):728-39.
  14. Jin, S.-L.C., S. Goya, N. Susumu, D. Wang, M. Bruss, C. Hou, D. Umetsu, and M. Conti. Phosphodiesterase 4B is essential for Th2 cell function and development of airway hyperresponsiveness in allergic asthma. J. Allergy Clin. Immunol. 126(6):1252-1259 (2010).
  15. Bruss, M., W. Richter, K. Horner, S.-L.C. Jin, and M. Conti. Critical role of PDE4D in β2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. J. Biol. Chem. 283(33):22430-42 (2008).
  16. Zhang H.T., Y. Huang, A. Masood, L.R. Stolinski, Y. Li, L. Zhang, D. Dlaboga, S.-L.C. Jin,M. Conti, and J.M. O'donnell. Anxiogenic-like behavioral phenotype of mice deficient in Phosphodiesterase 4B (PDE4B). Neuropsychopharmacology 33(7):1611-23 (2008).
  17. Peter, D., S.-L.C. Jin, M. Conti, A. Hatzelmann, and C. Zitt. Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: Predominant role of PDE4D. J. Immunol. 178:4820-31 (2007).
  18. Lehnart, S.E., X.H. Wehrens, S. Reiken, S. Warrier, A.E. Belevych, R.D. Harvey, W. Richter, S.-L.C. Jin, M. Conti, and A.R. Marks: Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 123(1):25-35 (2005).
  19. Jin, S.-L.C., L. Lan, M. Zoudilova, and M. Conti: Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages. J. Immunol. 175(3):1523-31 (2005).
  20. Richter W., S.-L.C. Jin, and M. Conti: Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue. Biochem J. 388:803-11 (2005).
  21. Xiang, Y., F. Naro, M. Zoudilova, S.-L.C. Jin, M. Conti, and B. Kobilka: Phosphodiesterase 4D is required for 2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc. Natl. Acad. Sci. USA 102(3):909-14 (2005).
  22. Ariga, M., B. Neitzert, S. Nakae, G. Mottin, C. Bertrand, M.P. Pruniaux, S.-L.C. Jin, and M. Conti: Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J. Immunol. 173(12):7531-8 (2004).
  23. Masciarelli, S., K. Horner, C. Liu, S. H. Park, M. Hinckley, S. Hockman, T. Nedachi, S.-L.C. Jin, M. Conti, and V. Manganiello: Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J. Clin. Invest. 114(2):196-205 (2004).
  24. Park, J.-Y., Y.-Q. Su, M. Ariga, E. Law, S.-L.C. Jin, and M. Conti: Paracrine role of EGF-like growth factors in the ovulatory follicle. Science 303(5658):682-4 (2004)
  25. Mehats, C., S.-L.C Jin, J. Wahlstrom, E. Law, D.T. Umetsu and M. Conti: PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB J. 17:1831-1841 (2003).
  26. Park, J.-Y., F. Richard, S.Y. Chun, J.H. Park, E. Law, K. Horner, S.-L.C. Jin, and M. Conti: Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle. Mol. Endocrinol. 17:1117-1130 (2003).
  27. Robichaud, A., P.B. Stamatiou, S.-L.C. Jin, N. Lachance, D. MacDonald, F. Laliberte, S. Liu, Z. Huang, M. Conti and C.-C. Chan: Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J. Clin. Invest. 110:1045-1052 (2002).
  28. Zhang, H.-T., Y. Huang, S.-L.C. Jin, S.A. Frith, N. Suvarna1, M. Conti and J.M. O'Donnell: Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmcol. 27:587-95(2002).
  29. Jin, S.-L.C., and M. Conti: Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF- responses. Proc. Natl. Acad. Sci. USA 99:7628-7633 (2002).
  30. Verde, I., G. Pahlke, M. Salanova, G. Zhang, S. Wang, D. Coletti, J. Onuffer, S.-L.C. Jin and M. Conti: Myomegalin is a novel protein of the Golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. J. Biol. Chem. 276:11189-11198 (2001).
  31. Hansen, G*., S.-L.C. Jin*, D.T. Umetsu and M. Conti: Absence of muscarinic cholinergic-induced airway hyperreactivity in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc. Natl. Acad. Sci. USA 97:6751-6756 (2000). * Both made an equal contribution.
  32. Jin, S.-L.C., F.J. Richard, W.-P. Kuo, A.J. D’Ercole and M. Conti: Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. USA 96:11998-12003 (1999).
  33. Jin, S.-L.C., T. Bushnik, L. Lan and M. Conti: Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases: differential targeting and activation of the splicing variants derived from the PDE4D gene. J. Biol. Chem. 273:19672-19678 (1998).
  34. Moss, M.L., S.-L.C. Jin, J.D. Becherer, D.M. Bickett, W. Burkhart, W.J. Chen, D. Hassler, M.T. Leesnitzer, G. McGeehan, M. Milla, M. Moyer, W. Rocque, T. Seaton, F. Schoenen, J. Warner, and D. Willard: Structural features and biochemical properties of TNF-alpha converting enzyme (TACE). J. Neuroimmunol. 72:127-9 (1997).
  35. Moss, M.L., S.-L.C. Jin, M.E. Milla, W. Burkhart, H.L. Carter, W.-J. Chen, W.C. Clay, J.R. Didsbury, D. Hassler, C.R. Hoffman, T.A. Kost, M.H. Lambert, M.A. Leesnitzer, P. McCauley, G. McGeehan, J.Mitchell, M.Moyer, G. Pahel, W. Rocque, L.K. Overton, F. Schoenen, T. Seaton, J.-L. su, J.Warner, D. Willard and J.D. Becherer: Cloning of a disintegrin metalloproteinase that processes precursor tumor-necrosis factor-. Nature 385:733-736 (1997).
  36. Verghese, M.W., R.T. McConnell, J.M. Lenhard, L. Hamacher, and S.-L.C. Jin: Regulation of distinct cAMP-specific phosphodiesterase (PDE4) isozymes in human monocytic cells. Mol. Pharm. 47:1164-1171 (1995).
  37. Bates, M.D., C.L. Olsen, B.N. Becker, F.J. Albers, J.P. Middleton, J.G. Mulheron, S.-L.C. Jin, M. Conti and J.R. Raymond: Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells: studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. J. Biol. Chem. 268:14757-14763 (1993).
  38. Repaske, D.R., J.V. Swinnen, S.-L.C. Jin, J.J. Van Wyk and M. Conti: A polymerase chain reaction strategy toidentify and clone cyclic nucleotide phospho-diesterase cDNAs: molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J. Biol. Chem. 267:18683-18688 (1992).
  39. Jin, S.-L.C., J.V. Swinnen and M. Conti: Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase: mapping of the catalytic domain. J. Biol. Chem. 267:18929-18939 (1992).
  40. Jin, S.-L.C., M.A. Hynes, J.G. Simmons, J.M. Lauder and P.K. Lund: Ontogeny of glucagon messenger RNA in the rat pancreas. Histochemistry 97:431-438 (1992).
  41. Jin, S.-L.C., M.A. Hynes and P.K. Lund: Ontogeny of glucagon messenger RNA and encoded precursor in the rat intestine. Regulatory Peptides 29:117-131 (1990).
  42. Hynes, M.A., S.-L.C. Jin, M.H. Ulsen, J.G. Simmons and P.K. Lund: Characterization, localization and regulation of extrapancreatic proglucagon mRNAs. Biomedical Res. 9 (Suppl. 3):147-155 (1988).
  43. Jin, S.-L.C., V.K.M. Han, J.G. Simmons, A.C. Towle, J.M. Lauder and P.K.Lund:Distribution of glucagon-like peptide I (GLP-I), glucagon and glicentin in the rat brain: An immunocytochemical study. J. Comp. Neurol. 271:519-532 (1988).
  44. Han, V.K.M., M.A. Hynes, S.-L.C. Jin, A.C. Towle, J.M. Lauder and P.K. Lund: Cellular localization of proglucagon/glucagon-like peptide I messenger RNAs in rat brain. J. Neurosci. Res. 16:97-107 (1986).
  45. Adams, M.W.W., S.-L.C. Jin, J.-S. Chen and L.E. Mortenson: The redox properties and activation of the F420-non-reactive hydrogenase of Methano-bacterium formicicum. Biochem. Biophys. Acta 869:37-47 (1986).
  46. Jin, S.-L.C., D.K. Blanchard and J.-S. Chen: Two hydrogenases with distinct electron-carrier specificity and subunit composition in Methanobacterium formicicum. Biochem. Biophys. Acta 748:8-20 (1983).
  47. Jin, S.-L.C. and W.J. Bleier: Renal morphology of Macrotus (Chiroptera, Phyllostomatidae). J. Mamm. 62:181-182 (1981).

Reviews and Chapters

  1. Jin, S.-L.C., Ding SL, and Lin SC. Phosphodiesterase 4 and its inhibitors in inflammatory diseases. Chang Gung Med. J. 35(3):197-210. (2012)
  2. Jin, S.-L.C., W. Richter, and M. Conti: Insights into the physiological functions of PDE4s from knockout mice. In: “Cyclic Nucleotide Phosphodiesterases in Health and Disease”, J. Beavo, S. Francis, and M. Houslay (eds), CRC Press LLC, pp. 323-346 (2007).
  3. Jin, S.-L.C., A.M. Latour, and M. Conti: Generation of PDE4 knockout mice by gene targeting. In Phosphodiesterase Methods and Protocols (C. Lugnier, ed.). In the series of Methods in Molecular Biology. Humana Press, New Jersey. 307:191-210 (2005).
  4. Conti, M., W. Richter, C. Mehats, G. Livera, J.-Y. Park, and S.-L.C. Jin: Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. J. Biol. Chem. 278:5493-5496 (2003).
  5. Conti, M., C.B. Andersen, F.J. Richard, C. Mehats, S.-Y. Chun, K. Horner, S.-L.C. Jin and A. Tsafriri: Role of cyclic nucleotide signaling in oocyte maturation. Mol. Cell. Endocrinol. 187:153-159 (2002).
  6. Mehats, C., C.B. Andersen, M. Filopanti, S.-L.C. Jin and M. Conti: Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrinol. Metab. 13:29-35 (2002).
  7. Conti, M. and S.-L.C. Jin: The molecular biology of cyclic nucleotide phosphodiesterases. Prog. Nucleic Acid Res. and Mol. Biol. 63:1-38 (1999).
  8. Salanova, M., S.-L.C. Jin and M. Conti: Heterologous expression and purification of recombinant rolipram-sensitive cyclic AMP- specific phosphodiesterases. Methods: A Companion to Methods in Enzymology 14:55-64 (1998).
  9. Conti, M., J.V. Swinnen, S.-L.C. Jin, J.E. Welch, D.A. O’Brian, and E.M. Eddy: Structure and regulation of gonadal cell phosphodiesterases. In: “Molecular Basis of Reproductive Endocrinology”, P.C.K. Leung, A.J.W. Hsueh and H.G. Griesen (eds), Serono Symposia, USA, pp. 144-155 (1993).
  10. Conti, M., J.V. Swinnen, K.E. Tsikalas and S.-L.C. Jin: Structure and regulation of the rat high affinity cAMP phosphodiesterases: a family of closely related enzymes. In: “Advances in Second Messenger and Phosphoprotein Research”, Vol. 25, S.J. Strada and H. Hidaka (eds), Raven Press Ltd., New York, pp. 87-99 (1992).
  11. Conti, M., S.-L.C. Jin, L. Monaco, D.R. Repaske and J.V. Swinnen: Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocrine Reviews 12:218-234 (1991).
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