專任教授(生物醫學組)-中央大學生命科學系資訊網

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系所成員

專任教授(生物醫學組)

  • 發佈日期: 2020-03-26
  • 最後更新日: 2021-11-29
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  • 瀏覽人次:4933

吳沛翊 博士

  • 職稱: 助理教授
  • 學歷: 國立台灣大學生命科學系博士
  • 專長: 細胞生物學、癌症生物學、組織學、解剖學
  • 信箱: pywu@ncu.edu.tw
  • 分機: 65086、65076
現職與學經歷
  • 現  職:
  1. 國立中央大學 生命科學系 助理教授 (2020~present)
  • 學  歷:
  1. 國立台灣大學 生命科學系 博士 (2007~2013)
  2. 國立成功大學 細胞生物與解剖學研究所 碩士 (2003~2005)
  3. 國立成功大學 生命科學系 學士 (1999~2003)
  • 經  歷
  1.  國立中央大學 生命科學系 助理教授 (2020~present)
  2.  中央研究院細胞與個體生物學研究所 博士後研究員 (2019~2020)
  3.  日本京都大學生命科學研究所 訪問學者 (2018~ 2019)
  4.  中央研究院細胞與個體生物學研究所 博士後研究員 (2015~2018)
  5.  國立台灣大學電機工程學系/生命科學系 博士後研究員 (2014~2014)




授課與研究領域

           大學部

  1. 生物化學    
  2. 普通生物學
  3. 細胞生物學
  4. 分子細胞生物學
  5. 書報討論    


  • 研究領域
  1. 細胞生物學
  2. 癌症生物學
  3. 神經退化性疾病






論文發表
  • Research Papers:

  1. Wu PY, Yu IS, Lin YC, Chang YT, Chen CC, Lin KH, Tseng TH, Kargren M, Tai YL, Shen TL, Liu YL, Wang BJ, Chang CH, Chen WM, Juan HF, Huang SF, Chan YY, Liao YF, Hsu WM, and Lee H. Activation of aryl hydrocarbon receptor by kynurenine impairs the progression and metastasis of neuroblastoma. Cancer Res. 2019 Nov 1;79(21):5550-5562. doi: 10.1158/0008-5472. (IF: 8.378, Oncology 21/230)
  2. Wu PY, Chuang PY, Chan YY, Tsai TC, Wang BJ, Lin KH, Hsu WM, Liao YF, and Lee H. Novel Endogenous Ligands of Aryl Hydrocarbon Receptor Mediate Neural Development and Differentiation of Neuroblastoma. ACS Chem Neurosci. 2019 Sep 18;10(9):4031-4042. doi: 10.1021/acschemneuro.9b00273. (IF: 3.861, Chemistry, Medicinal 13/61)
  3. Wu PY*, Lin YC*, Huang YL, Chen WM, Chen CC, Lee H. Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer. Cancers (Basel). 2018 Oct 31;10(11). pii: E413. doi: 10.3390/cancers10110413. (IF: 6.162, Oncology 31/230) * Joint first author
  4. Wang BJ*, Wu PY*, Chen YW*, Chang YT, Bhore N, Wu PF, Liao YF. Quantitative measurement of γ-Secretase-mediated amyloid precursor protein and notch cleavage in cell-based luciferase reporter assay platforms. J Vis Exp. 2018 Jan 25;(131). doi: 10.3791/56795. (IF: 1.108, Multidisciplinary science 41/69)    * Joint first author
  5. Weng WC*, Lin KH*, Wu PY*, Ho YH, Liu YL, Wang BJ, Liao YF, Lee WT, Hsu WM, and Lee H. VEGF expression correlates with neuronal differentiation and predicts a favorable prognosis in patients with neuroblastoma. Sci Rep. 2017 Sep 11;7(1):11212. (IF: 4.011, Multidisciplinary science 15/69) * Joint first author
  6. Wang BJ, Her GM, Hu MK, Chen YW, Tung YT, Wu PY, Hsu WM, Lee H, Jin LW, Hwang SL, Chen RP, Huang CJ, Liao YF. ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15): E3129-E3138. (IF: 9.58, Multidisciplinary science 7/69)
  7. Hsu WM, Huang CC, Lee HY, Wu PY, Wu MT, Chuang HC, Lin LL, Chuang JH. MDA5 complements TLR3 in suppression of neuroblastoma. Oncotarget. 2015 Sep 22;6(28):24935-46.
  8. Weng WC, Lin KH, Wu PY, Lu YC, Weng YC, Wang BJ, Liao YF, Hsu WM, Lee WT, Lee H. Calreticulin Regulates VEGF-A in Neuroblastoma Cells. Mol Neurobiol. 2015 Aug;52(1):758-70. (IF: 4.586, Neuroscience 57/267)
  9. Kuo CT*, Chuang FT*, Wu PY*, Lin YC, Liu HK, Huang GS, Tsai TC, Chi CY, Wo AM, Lee H and Lee SC. Experimental demonstration of bindingless signal delivery in human cells via microfluidics. Journal of Applied Physics. 2014 Jul;116: 044702. (IF: 2.328, Physics, Applied 59/148) *Joint first author
  10. Lu YC, Chen CN, Chu CY, Lu J, Wang BJ, Chen CH, Huang MC, Lin TH, Pan CC, Chen SS, Hsu WM, Liao YF, Wu PY, Hsia HY, Chang CC, Lee H. Calreticulin activates β1 integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells. Biochem J. 2014 May 15;460(1):69-78. (IF: 4.331, Biochemistry & Molecular Biology 73/299)
  11. Wu PY, Liao YF, Juan HF, Huang HC, Wang BJ, Liu YL, Yu IS, Shih YY, Jeng YM, Hsu WM, Lee H. Aryl hydrocarbon receptor downregulates MYCN expression and promotes cell differentiation of neuroblastoma. PLoS One. 2014 Feb 21;9(2): e88795. (IF: 2.776, Multidisciplinary science 24/69)
  12. Wu PY, Lin YC, Lan SY, Huang YL, Lee H. Aromatic hydrocarbon receptor inhibits lysophosphatidic acid-induced vascular endothelial growth factor-A expression in PC-3 prostate cancer cells. Biochem Biophys Res Commun. 2013 Aug 2;437(3):440-5. (IF: 2.705, Biochemistry & Molecular Biology 157/299)
  13. Hsu WM, Huang CC, Wu PY, Lee H, Huang MC, Tai MH, Chuang JH. Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma. Cancer Lett. 2013 Aug 19;336(2):338-46. (IF: 6.508, Oncology 29/230)
  14. Wang BJ, Wu PY, Lu YC, Chang CH, Lin YC, Tsai TC, Hsu MC, Lee H. Establishment of a cell-free bioassay for detecting dioxin-like compounds. Toxicol Mech Methods. 2013 Jul;23(6):464-70. (IF: 2.276, Toxicology 58/93)
  15. Lu MY, Liu YL, Chang HH, Jou ST, Yang YL, Lin KH, Lin DT, Lee YL, Lee H, Wu PY ,Luo TY, Shen LH, Huang SF, Liao YF, Hsu WM, Tzen KY; National Taiwan University Neuroblastoma Study Group. Characterization of neuroblastic tumors using 18F-FDOPA PET. J Nucl Med. 2013 Jan;54(1):42-9. (IF: 7.308, Radiology, Nuclear Medicine & Medical Imaging 5/129)
  16. Huang TC, Chang HY, Chen CY, Wu PY, Lee H, Liao YF, Hsu WM, Huang HC, Juan HF. Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR and repressing MYCN. FEBS Lett. 2011 Nov 16;585(22):3582-6. (IF: 2.675, Biochemistry & Molecular Biology 157/299)





榮譽事項
  • Award Received
  1. 11/16 Excellent Poster Award of Institute of Cellular and Organismic Biology, Academia Sinica.
  2. 11/15 Best Poster Award of Asia-Pascific Symposium of Neuroblastoma.
  3. 06/13 Poster Award of Science Fair of College of Life science, NTU
  4. 06/10 Poster Award of Translational Science- Animal Biotechnology Symposium
  5. 06/10 NTU Teaching Assistant Award









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