專任教授(生物醫學組)-中央大學生命科學系資訊網

• 現  職：

1. 國立中央大學 生命科學系 副教授 (2023~present)

• 學  歷：

1. 國立成功大學 基礎醫學研究所 博士 (2001~2008)
2. 國立成功大學 微生物暨免疫學研究所 碩士 (1999~2001)
3. 國立成功大學 生命科學系 學士 (1994~1999)
   

• 經  歷：

1. 國立中央大學 生命科學系 副教授 (2023~present)
   
2. 國立中央大學 生命科學系 助理教授 (2018~2023)
3. 國家衛生研究院國家環境醫研究所 博士後研究員 (2011~2018)
4. 國立成功大學微免所追求卓越計畫 博士研究員 (2008~2010)
5. 醫學院 (醫學系、醫技系、護理系) 免疫學實驗助教 (2001~2008)
6. 醫學院 (醫學系、醫技系、護理系) 微生物實驗助教 (1999~2001)

• 授  課
  大學部
  
  1. 普通生物學
  2. 微生物學
  3. 動物生理學
     
  研究所
  
  1. 感染與免疫
  2. 奈米醫學與免疫療法的進展
  3. 專題研究：免疫毒理研究
  
  

• 研究領域
  

  1.細胞生物學、腫瘤生物學

  2.免疫毒理、感染與免疫

  3. 奈米/藥物安全與效用評估

  4 動物試驗替代測試方法:
  OECD測試規範 (皮膚刺激/腐蝕、嚴重眼損傷/眼刺激、皮膚致敏)

1. Arrokhman S, Luo YH, Lin P * (2023) Additive cardiotoxicity of a bisphenol mixture in zebrafish embryos: The involvement of calcium channel and pump. Ecotoxicology and Environmental Safety, 10.1016/j.ecoenv.2023.115225 (IF=6.8; SCI, R/C=6/94, TOXICOLOGY)
2. HsuWL, Wang CM, Yao CL, Chen SC, Nien CY, Sun YH, Tseng TY, Luo YH* (2022) Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through P62-Keap-1-Nrf2 axis, Cell Death & Disease, 13(12):1060 (IF=9.0; SCI, R/C=31/191, CELL BIOLOGY)
3. Wahyuni EA, Yii CY, Liang HL, Luo YH, Yang SH, Wu PY, Hsu WL, Nien CY*, Chen SC* (2022). Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells, Chemico-Biological Interactions, 365:110046 (IF=5.11; SCI, R/C=57/277，PHARMACOLOGY & PHARMACY)
4. Jhong JH, Tsai WH, Yang LC, Chou CH, Lee TY, Yeh YT, Huang CH and Luo YH* (2022). Heat-killed Lacticaseibacillus paracasei GMNL-653 exerts antiosteoporotic effects by restoring the gut microbiota dysbiosis in ovariectomized mice, Frontiers in Nutrition, 9:804210 (IF=5.0; SCI, R/C=28/88, NUTRITION & DIETETICS)
5. Lee CW, Hsu LF, Wu I.L, Wang YL, Chen WC, Liu YJ, Yang LT, Tan CL, Luo YH, Wang CC, Chiu HW, Yang TCK, Lin YY, Chang HA, Chiang YC, Chen CH, Lee MH, Peng KT, Huang CCY * (2022) Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice. Journal of Hazardous Materials, 430: 128431. (IF=13.6; SCI, R/C=10/274, ENVIRONMENTAL SCIENCES)
   
6. Nguyen MHT, Luo YH, Li AL, Tsai JC, Wu KL, Chung PJ, Ma N *(2021). miRNA as a modulator of immunotherapy and immune response in melanoma. Biomolecules, 11(11):1648. (IF=5.5; SCI, R/C=70/285, BIOCHEMISTRY & MOLECULAR BIOLOGY)
7. Gudivada VN, Huang CJ, Luo YH, and Dong GC * (2021) A cyclic BMP-2 peptide upregulates bmp-2 protein-induced cell signaling in myogenic cells. Polymers (Basel), 13(15): 2549. (IF=5.0; SCI, R/C=16/86, POLYMER SCIENCE)
8. Lin HD, Yao CL, Ou WJ, Luo YH, Chen SC* (2020). 4-Aminobiphenyl suppresses homologous recombination repair by a reactive oxygen species-dependent p53/miR-513a-5p/p53 loop. Toxicology, 444, 152580. (IF=4.5; SCI, R/C=16/94, TOXICOLOGY)
9. Luo YH*, Cheng HJ, Tsai FY, Tsou TC, Lin SY, Lin P.* (2020). Primary amine modified gold nanodots regulate macrophage function and antioxidant response: potential therapeutics targeting of Nrf2. International Journal of Nanomedicine, 15, 8411-8426. (IF=8.0; SCI, R/C=18/277, PHARMACOLOGY&PHARMACY). (* Correspondence)
10. Luo YH, Kuo YC, Tsai MH, Ho CC, Tsai HT, Hsu CY, Chen YC, Lin P*. (2017) Interleukin-24 as a target cytokine of environmental aryl hydrocarbon receptor agonist exposure in the lung. Toxicology and applied pharmacology. 324:1-11 (IF=3.8; R/C=29/94, TOXICOLOGY)
11. Ho CC, Lee HL, Chen CY, Luo YH, Tsai MH, Tsai HT, Lin P*. (2017) Involvement of the cytokine-IDO1-AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation. Nanotoxicology. 11(3):360-370 (IF=5.0; R/C=14/94, TOXICOLOGY)
12. Ho CC, Luo YH, Chuang TH, Lin P*. (2016) Quantum dots induced interferon beta expression via TRIF-dependent signaling pathways by promoting endocytosis of TLR4. Toxicology. 344-346:61-70 (IF=4.5; SCI, R/C=16/94, TOXICOLOGY)
13. Luo YH, Wu ZW, Tsai HT, Lin SY, Lin P*. (2015) Endotoxin nanovesicles: hydrophilic gold nanodots control supramolecular lipopolysaccharide assembly for modulating immunological responses. Nano letters. 15(10):6446-6453 (IF=10.8; R/C=21/178, CHEMISTRY, MULTIDISCIPLINARY)
14. Luo YH, Chang LW, and Lin P*. (2015) Metal-based nanoparticles and the immune system: activation, inflammation and potential applications. BioMed Research International. 143720. (IF=3.246; R/C=90/159, BIOTECHNOLOGY & APPLIED MICROBIOLOGY)
15. Cheng HJ, Luo YH, Lei HY, Lin CF, Wang ST, Chen KJ, Hung NT, Liu CC, Liu HS, Yeh TM, Lin YS*. (2015) Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1. American Journal of Tropical Medicine and Hygiene. 92(5):989-95. (IF=3.3; R/C=4/24, TROPICAL MEDICINE)
16. Lu SL, Tsai CY, Luo YH, Kuo CF, Lin WC, Chang YT, Wu JJ, Chuang WJ, Liu CC, Chao L, Chao J, Lin YS*. (2013) Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group a streptococcal infection. Antimicrobial Agents and Chemotherapy. 57(11):5366-5372. (IF=4.9; R/C=62/277, PHARMACOLOGY & PHARMACY)
17. Ho CC, Luo YH, Chuang TH, Yang CS, Ling YC, Lin P*. (2013) Quantum dots induced monocyte chemotactic protein-1 expression via MyD88-dependent Toll-like receptor signaling pathways in macrophages. Toxicology. 308:1-9. (IF=4.5; SCI, R/C=16/94, TOXICOLOGY)
18. Luo YH, Wu SB, Wei YH, Chen YC, Tsai MH, Yang CS, Lin P*. (2013) Cadmium-based quantum dot induced autophagy formation for cell survival via oxidative stress. Chemical Research in Toxicology. 26:662-673. (IF=4.1; R/C=25/94, TOXICOLOGY)
19. Li MH*, Luo YH*, Lin CF, Chang YT, Hong JS, Lin YS. (*equal contribution) (2011) Dextromethorphan efficiently increases bactericidal activity, attenuates inflammatory responses, and prevents group A streptococcal sepsis. Antimicrobial Agents and Chemotherapy. 55:967-973. (IF=4.9; R/C=62/277, PHARMACOLOGY & PHARMACY)
20. Luo YH, Chuang WJ, Wu JJ, Lin MT, Liu CC, Lin PY, Roan JN, Wong TW, Chen YL, Lin YS*. (2010) Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells. Laboratory Investigation. 90:1492-1506. (IF=5.0; R/C=51/136, MEDICINE, RESEARCH & EXPERIMENTAL)
21. Cheng HJ, Lei HY, Lin CF, Luo YH, Wan SW, Liu HS, Yeh TM, Lin YS*. (2009) Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation. Molecular Immunology. 47:398-406. (IF=3.6; R/C=99/161, IMMUNOLOGY)
22. Cheng HJ, Lin CF, Lei HY, Liu HS, Yeh TM, Luo YH, Lin YS*. (2009) Proteomic analysis of endothelial cell autoantigens recognized by anti-dengue virus nonstructural protein 1 antibodies. Experimental Biology and Medicine. 234:63-73. (IF=3.2; R/C=84/136, MEDICINE, RESEARCH & EXPERIMENTAL)
23. Luo YH, Kuo CF, Huang KJ, Wu JJ, Lei HY, Lin MT, Chuang WJ, Liu CC, Lin CF, Lin YS*. (2007) Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis. Kidney International. 72:716-724. (IF=19.6; R/C=3/88, UROLOGY & NEPHROLOGY)
24. Kuo CF, Chen CC, Lin CF, Jan MS, Huang RY, Luo YH, Chuang WJ, Sheu CC, Lin YS*. (2007) Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines. Food and Chemical Toxicology. 45:278-285. (IF=4.3; R/C=43/142, FOOD SCIENCE & TECHNOLOGY)
25. Kuo CF, Chen CC, Luo YH, Huang RY, Chuang WJ, Sheu CC, Lin YS*. (2005) Cordyceps sinensis mycelium protects mice from group A streptococcal infection. Journal of Medical Microbiology. 54:795-802. (IF=3.0; R/C=84/135, MICROBIOLOGY)
26. Wang CH, Lin CY, Luo YH, Tsai PJ, Lin YS, Lin MT, Chuang WJ, Liu CC, Wu JJ*. (2005) Effects of oligopeptide permease in group A streptococcal infection. Infection and Immunity. 73:2881-2890. (IF=3.1; R/C=62/96, INFECTIOUS DISEASES)
27. Kuo CF, Luo YH, Lin HY, Huang KJ, Wu JJ, Lei HY, Lin MT, Chuang WJ, Liu CC, Jin YT, Lin YS*. (2004) Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection. Microbial Pathogenesis. 36:273-285. (IF=3.8; R/C=64/156，MICROBIOLOGY)
    

專書

1. Luo YH, Chang LW., Lin P. Immune Aspects of Biopharmaceuticals and Nanomedicines Edited ByRaj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette (1st Edition) (ISBN: 9780203731536). New York: Jenny Stanford Publishing. Jan, 2019. Chapter 22 Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications.

研討會論文

1. HsuWL, Wang CM, Yao CL, Chen SC, Nien CY, Sun YH, Tseng TY, Luo YH*(2023) Blockage of Nrf2 and Autophagy by L-selenocystine Induces Selective Death in Nrf2-addicted Colorectal Cancer Cells through p62-Keap-1-Nrf2 Axis. 2023 NHRI-NCU JOINT RESEARCH CONFERENCE (2023國衛院-中央大學聯合學術研討會)

2. Peng YW, Wang CM, Chiang-Ni C, Luo YH (2023) Extracellular vesicles secreted by invasive Group A Streptococcus mediate murine Raw264.7 macrophages activations 2023 NHRI-NCU JOINT RESEARCH CONFERENCE (2023國衛院-中央大學聯合學術研討會)

3. Chen RY, Hsu WL, Sun YT, Lin CAJ., Luo YH (2023). L-selenocystine-containing gold nanoparticles impede COX-2 and PD-L1 in Nrf2-addicted colorectal cancer. 2023 NHRI-NCU JOINT RESEARCH CONFERENCE (2023國衛院-中央大學聯合學術研討會)

4. HsuWL, Wang CM, Yao CL, Chen SC, Nien CY, Sun YH, Tseng TY, Luo YH*(2023) Blockage of Nrf2 and Autophagy by L-selenocystine Induces Selective Death in Nrf2-addicted Colorectal Cancer Cells through p62-Keap-1-Nrf2 Axis. 2023 The 37^th Joint Annual Conference of Biomedical Science 2023生物醫學聯合學術年會

5. Wang CM (王傑民), Hsu WL (徐偉倫), Chen SC, Yao CL, Luo YH (2022) Overwhelming Oxidative Stress Sensitized Colorectal Carcinoma to Selenocompound-Induced Cell Death via IRE1-CHOP Axis. 2022 NHRI-NCU JOINT RESEARCH CONFERENCE (2022國衛院-中央大學聯合學術研討會)

6. Lin YJ (林晏如), Lin P, and Luo YH (2022) Adverse effects of PM2.5 exposure in human colonic adenocarcinoma Caco2 cells-oxidative stress, cell proliferation, and autophagy flux impairment. 2022 NHRI-NCU JOINT RESEARCH CONFERENCE (2022國衛院-中央大學聯合學術研討會)

7. Sun YH (孫揚和), Hsu WL (徐偉倫), Wang CM (王傑民), Chen RY (陳柔妤), Luo YH (2022) To investigate the role of Nrf2 inhibition by selenocompound in cisplatin-resistant colorectal cancer cells. 2022 NHRI-NCU JOINT RESEARCH CONFERENCE (2022國衛院-中央大學聯合學術研討會)

8. Lien HY (連信詠), Luo YH (2022) Effects of bacterial extracellular vesicle of Group A streptococcus on inflammation in murine RAW264.7 macrophages. 2022 NHRI-NCU JOINT RESEARCH CONFERENCE (2022國衛院-中央大學聯合學術研討會)

9. Wang CM (王傑民), Hsu WL (徐偉倫), Sun YH (孫揚和), Chen SC, Luo YH (2021) Selenocompound induces oxidative stress and endoplasmic reticulum stress, and disrupts adhesion ability in human colorectal adenocarcinoma. 2021 NHRI-NCU JOINT RESEARCH CONFERENCE (2021國衛院-中央大學聯合學術研討會)

10. Hsu WL (徐偉倫), Wang CM (王傑民), Chen SC, Yao CL, Luo YH (2021) Compound X induce cell death through Nrf2 inhibition, autophagy downregulation and oxidative stress in Nrf2-addicted colorectal cancer cells. 2021 NHRI-NCU JOINT RESEARCH CONFERENCE (2021國衛院-中央大學聯合學術研討會)

11. Wang SP (王碩平), Chen Xin (陳忻), Lin P and Luo YH (2020) Environmental particulate matter induces intestinal inflammatory responses and cell proliferation in human colorectal epithelial cells. 2020 NHRI-NCU JOINT RESEARCH CONFERENCE (2020國衛院-中央大學聯合學術研討會)

12. Hsu WL (徐偉倫), Wang CM (王傑民), Chen SC, Yao CL, Luo YH (2020) L-selenocysteine modulate autophagy formation and Nrf2 activation through ROS-dependent manner in colorectal cancer cells. 2020 NHRI-NCU JOINT RESEARCH CONFERENCE (2020國衛院-中央大學聯合學術研討會)

13. Luo YH (2019). Surface modifications of gold nanodots modulate antioxidative responses and phagocytic ability via Nrf2-dependent mechanism in human macrophages. 2019 桃園四校生命科技領域聯合學術研討會

14. Luo YH (2019). Effects of air pollution PM2.5 on intestinal health. 2019 NCU-Landseed Chronic Disease Symposium (2019中大聯新聯合慢性病研討會)

15. Luo YH, Tsai HT, Tsai FY, Tsou TC, Lin SY, and Lin P (2018). Surface modifications of gold nanodots modulate antioxidative responses and phagocytic ability via Nrf2-dependent mechanism in human macrophages. ASIATOX 2018, Thailand.

16. Luo YH, Lin P. (2016). Endotoxin nanovesicles: Hydrophilic gold nanodots control supramolecular lipopolysaccharide assembly for modulating immunological responses. 2016 International Particle Toxicology Conference (11th IPTC), Singapore.

專利

台灣專利: 專利核准

申請案號: 105106483

發明名稱: 內毒素奈米微粒:親水性奈米金控制內毒素聚集結構形成奈米微粒進而調節免疫反應。

年度榮譽事項

111年

1. 111學年度研究傑出獎

110年

1. 110學年度研究傑出獎

109年

1. 國立中央大學新聘傑出教研人員獎勵
2. 109學年度院教學優良獎

1. 國立中央大學新聘傑出教研人員獎勵
   

1. 台灣毒物學學會