Full-time Professors (Plant, Microbial and Environmental Biology)-Department of Life Sciences, NCU

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HOMEFacultyFull-time Professors (Plant, Microbial and Environmental Biology)Dr. Chung-An Lu

Faculty

Full-time Professors (Plant, Microbial and Environmental Biology)

  • Release: 2022-02-10
  • Update: 2022-02-11
  • Source：
  • Visits：1739

Dr. Chung-An Lu

  • Job title: Distinguished Professor
  • Education: Institute of Life Science, National Defense Medical Collage, Taiwan
  • Expertise: Plant Gene Regulation, Plant Tissue Culture
  • mailbox: chungan@cc.ncu.edu.tw
  • Extension: 65077
Introduction
  1. Position: Distinguished Professor
  2. Education:
    1. Ph.D: 1992 - 1998, National Defense Medical Collage, Institute of Life Science
    2. M.S.: 1990 - 1992, Chinese Culture University, Institute of Biotechnology.
    3. B.S.: 1986 - 1990, Chinese Culture University, Department of Botany.
  3. Professional Experience:
    1. 2012-2020/7: Associate Professor, Dept. of Life Sciences, Natl. Central Univ.
    2. 2004-2012/7: Assistant Professor, Dept. of Life Sciences, Natl. Central Univ.
    3. 2003. 4~present: Postdoctoral Fellow, with Dr. Karen E. Koch and Dr. Donald R. McCarty, Department of Horticultural Sciences, University of Florida. Research on maize functional reverse genomics.
    4. 2000/6 - 2000/9: Visiting Postdoctoral Fellow, with Dr. Tuan-hua David Ho, Department of Biology, Washington University in St. Louis. Research on sugar and hormonal regulation of a-amylase gene expression.
    5. 1998/10 - 2003/3: Postdoctoral Fellow, with Dr. Su-May Yu, Institute of Molecular Biology, Academia Sinica. Research on mechanism of sugar-dependent transcriptional control of a-amylase gene expression.
  4. Current Position: 2012/8-present: Associate Professor, Dept. of Life Sciences, Natl. Central Univ.
  5. Contact:886-3-422-7151 ext 65067
  6. FAX:(03) 422-8482
  7. E-mail:chungan@cc.ncu.edu.tw
Research
Molecular Biology、Plant Signal Transduction、Plant Gene Regulation、 Plant Tissue Culture
Paper
  1. Nguyen TM., Lu CA*, Huang LF* (2021) Applications of CRISPR/Cas9 in a rice protein expression system via an intron-targeted insertion approach. (https://doi.org/10.1016/j.plantsci.2021.111132).
  2. Sinaga DS., Ho SL., Lu CA, Yu SM, Huang LF* (2021) Knockdown expression of a MYB-related transcription factor gene, OsMYBS2, enhances production of recombinant proteins in rice suspension cell. Plant Methods, 17, 99.
  3. Wang TY, Wu JR, Duong NKT, Lu CA, Yeh CH, Wu SJ* (2021) HSP70-4 and farnesylated AtJ3 constitute a specific HSP70/HSP40-based chaperone machinery essential for heat stress tolerance in Arabidopsis. JOURNAL OF PLANT PHYSIOLOGY, 261 113543.
  4. Fang JC, Tsai YC, Chou WL, Liu HY, Chang CC, Wu SJ, Lu CA* (2021) A CCR4-associated factor 1, OsCAF1B, confers tolerance of low-temperature stress to rice seedlings. Plant Mol Biol. 105, 177-192.
  5. Hsieh PH, Chung YH, Lee KT, Wang SY, Lu CA, Hsieh MH* (2021) The rice PALE1 homolog is involved in the biosynthesis of vitamin B1. Plant Biotechnol J. 2020, 1-3.
  6. Fang JC, Liu HY, Tsai YC, Chou WL, Chang CC, Lu CA* (2020) A CCR4 association factor 1, OsCAF1B, participates in the αAmy3 mRNA poly(A) tail shortening and plays a role in germination and seedling growth. Plant Cell Physiol. 61, 554-564.
  7. Lu CA*, Huang CK, Huang WS, Huang TS, Liu HY, Chen YF (2020) DEAD-Box RNA Helicase 42 Plays a Critical Role in Pre-mRNA Splicing under Cold Stress. Plant Physiol. 182, 255-271.
  8. Chen YS, Ho Tuan-Hua David , Liu L, Lee DH, Lee CH, Chen YR, Lin SY, Lu CA*, Yu SM*, (2019) Sugar starvation-regulated MYBS2 and 14-3-3 protein interactions enhance plant growth, stress tolerance, and grain weight in rice. PNAS. 116 (43): 21925-21935.
  9. Chen YS, Chao YC, Tseng TW, Huang CK, Lo PC, Lu CA* (2017) Two MYB-related transcription factors play opposite roles in sugar signaling in Arabidopsis. Plant Mol Biol. 93(3):299-311.
  10. Chou WL, Chung YL, Fang JC, Lu CA* (2017) Novel interaction between CCR4 and CAF1 in rice CCR4-NOT deadenylase complex. Plant Mol Biol. 93(1-2):79-96.
  11. Huang CK, Sie YS, Chen YF, Huang TS, Lu CA* (2016) Two highly similar DEAD box proteins, OsRH2 and OsRH34, homologous to eukaryotic initiation factor 4AIII, play roles of the exon junction complex in regulating growth and development in rice. BMC Plant Biol. 12;16(1):84.
  12. Huang CK, Shen YL, Huang LF, Wu SJ, Yeh CH, Lu CA* (2016) The DEAD-box RNA helicase AtRH7/PRH75 participates in pre-rRNA processing, plant development and cold tolerance in Arabidopsis. Plant Cell Physiol. 57 (1): 174-191.
  13. Wu TM, Lin KC, Liau WS, Chao YY, Yang LH, Chen SY, Lu CA, Hong CY* (2016). A set of GFP-based organelle marker lines combined with DsRed-based gateway vectors for subcellular localization study in rice (Oryza sativa L.). Plant Mol Biol. 90(1-2):107-15.
  14. Huang LF*, Tan CC, Yeh JF, Liu HY, Liu YK, Ho SL, Lu CA* (2015) Efficient Secretion of Recombinant Proteins from Rice Suspension-Cultured Cells Modulated by the Choice of Signal Peptide. PLoS ONE 10(10): e0140812
  15. (SCI; IF: 3.234; Ranking:9/57 in Multidisciplinary Sciences)
  16. Huang CK, Lo PC, Huang LF, Wu SJ, Yeh CH, Lu CA* (2015) A single-repeat MYB transcription repressor, MYBH, participates in regulation of leaf senescence in Arabidopsis. Plant Mol Biol. 88:269-86.
  17. (SCI; IF: 4.257; Ranking: 17/204 in Plant Sciences)
  18. Chen YS, Lo SF, Sun PK, Lu CA, Ho TH*, Yu SM* (2014) A late embryogenesis abundant protein HVA1 regulated by an inducible promoter enhances root growth and abiotic stress tolerance in rice without yield penalty. Plant Biotechnol J. 13:105-16.
  19. (SCI; IF: 5.752; Ranking: 11/204 in Plant Sciences)
  20. Chou WL, Huang LF, Fang JC, Yeh CH, Hong CY, Wu SJ, Lu CA*. (2014). Divergence of the expression and subcellular localization of CCR4-associated factor 1 (CAF1) deadenylase proteins in Oryza sativa. Plant Mol Biol. 85:443-58.
  21. (SCI; IF: 4.257; Ranking: 17/204 in Plant Sciences)
  22. Hsu KH, Liu CC, Wu SJ, Kuo YY, Lu CA, Wu CR, Lian PJ, Hong CY, Ke YT, Huang JH, Yeh CH*. (2014). Expression of a gene encoding a rice RING zinc-finger protein, OsRZFP34, enhances stomata opening. Plant Mol Biol. 86:125-37.
  23. (SCI; IF: 4.257; Ranking: 17/204 in Plant Sciences)
  24. Lin CR, Lee KW, Chen CY, Hong YF, Chen JL, Lu CA, Chen KT, Ho TH, Yu SM*. (2014). SnRK1A-interacting negative regulators modulate the nutrient starvation signaling sensor SnRK1 in source-sink communication in cereal seedlings under abiotic stress. Plant Cell. 26:808-27.
  25. (SCI; IF: 9.338; Ranking: 4/204 in Plant Sciences)
  26. Ho SL , Huang LF, Lu CA, He SL, Wang CC, Yu SP, Chen J, Yu SM* (2013). Sugar starvation- and GA-inducible calcium-dependent protein kinase 1 feedback regulates GA biosynthesis and activates a 14-3-3 protein to confer drought tolerance in rice seedlings. Plant Mol Biol. 81:347-361.
  27. (SCI; IF: 4.257; Ranking: 17/204 in Plant Sciences)
  28. Wang LC, Wu JR, Chang WL, Yeh CH, Ke YT, Lu CA, Wu SJ* (2013). Arabidopsis HIT4 encodes a novel chromocentre-localized protein involved in the heat reactivation of transcriptionally silent loci and is essential for heat tolerance in plants. J Exp Bot. 64:1689-1701.
  29. (SCI; IF: 5.526; Ranking: 12/204 in Plant Sciences) 
  30. Kuo YC, Tan CC, Ku JT, Hsu WC, Su SC, Lu CA, Huang LF * (2013). Improving Pharmaceutical Protein Production in Oryza sativa. Int J Mol Sci. 14: 8719-8739.
  31. (SCI; IF: 2.286; Ranking: 46/157 in Chemistry, Multidisciplinary)
  32. Hong YF, Ho TH, Wu CF, Ho SL, Yeh RH, Lu CA, Chen PW, Yu LC, Chao A, Yu SM* (2012). Convergent Starvation Signals and Hormone Crosstalk in Regulating Nutrient Mobilization upon Germination in Cereals. Plant Cell. 24: 2857–2873.
  33. (SCI; IF: 9.338; Ranking: 4/204 in Plant Sciences)
  34. Liu YK*, Huang LF, Ho SL, Liao CY, Liu HY, Lai YH, Yu SM, Lu CA* (2012) Production of mouse granulocyte-macrophage colony stimulating factor by Gateway technology and transgenic rice cell culture. Biotechnol Bioeng. 109:1239-1247.
  35. (SCI; IF: 4.126; Ranking: 24/163 in Biotechnology & Applied Microbiology)
  36. Lu KJ, Huang NC, Liu YS, Lu CA, Yu TS* (2012) Long-distance movement of Arabidopsis FLOWERING LOCUS T RNA participates in systemic floral regulation. RNA Biology 9:653-662.
  37. (SCI; IF: 4.974; Ranking: 52/290 in Biochemistry & Molecular Biology)
  38. Huang CK, Yu SM, Lu CA* (2010) A rice DEAD-box protein, OsRH36, can complement an Arabidopsis atrh36 mutant, but cannot functionally replace its yeast homolog Dbp8p. Plant Mol Biol. 74:119-128.
  39. Huang CK, Huang LF, Huang JJ, Wu SJ, Yeh CH, Lu CA* (2010) A DEAD-box protein, AtRH36, is essential for female gametophyte development and is involved in rRNA biogenesis in Arabidopsis. Plant Cell Physiol. 51(5):694-706.
  40. Wu SJ, Wang LC, Yeh CH, Lu CA, Wu SJ* (2010) Isolation and characterization of the Arabidopsis heat-intolerant 2 (hit2) mutant reveal the essential role of the nuclear export receptor EXPORTIN1A (XPO1A) in plant heat tolerance. New Phytol. 186(4):833-842.
  41. Guan JC, Yeh CH, Lin YP, Ke YT, Chen MT, You JW, Liu YH, Lu CA, Wu SJ, Lin CY*. (2010) A 9 bp cis-element in the promoters of class I small heat shock protein genes on chromosome 3 in rice mediates L-azetidine-2-carboxylic acid and heat shock responses. J Exp Bot. 61(15):4249-4261.
  42. Su CF, Wang YC, Hsieh TH, Lu CA, Tseng TH, Yu SM* (2010) A Novel MYBS3-dependent Pathway Confers Cold Tolerance in Rice. Plant Physiol. 153(1):145-58.
  43. Lee KW, Chen PW, Lu CA, Chen S, Ho TH.D. and Yu SM* (2009) Coordinated Responses to Oxygen and Sugar Deficiency Allow Rice Seedlings to Tolerate Flooding. Sci Signal. 6 October 2009: ra61.
  44. Wang LC, Yeh CH, Sayler RJ, Lee YY, Lu CA, Wu SJ* (2008) Arabidopsis HIT1, a putative homolog of yeast tethering protein Vps53p, is required for pollen tube elongation. Botanical Studies 49:25-32.
  45. Lu CA, Lin CC, Lee KW, Chen JL, Huang LF, Ho SL, Liu HJ, Hsing YI, Yu SM* (2007) The SnRK1A Protein Kinase Plays a Key Role in Sugar Signaling during Germination and Seedling Growth of Rice. Plant Cell. 19:2484-2499.
  46. Huang LF, Liu YK, Lu CA, Hsieh SL, Yu SM* (2005) Production of Human Serum Albumin by Metabolically Regulated Plant Cell Cultures. Transgenic Res. 14:569-81.
  47. Yong W, Link B, O'Malley R, Tewari J, Hunter CT, Lu CA, Li X, Bleecker AB, Koch KE, McCann MC, McCarty DR, Patterson SE, Reiter WD, Staiger C, Thomas SR, Vermerris W, Carpita NC (2005) Genomics of plant cell wall biogenesis. Planta. 221:747-51.
  48. Lee YC, Lu CA, Casaretto J, Yu SM (2003) A bZIP protein, OsBZ8, Mediates Sugar Repression of a-Amylase Gene Expression. Physiol Plant. 119:78-86.
  49. Lu CA, Ho TH D, Yu SM (2002) Three novel MYB proteins with single DNA-binding repeats mediate sugar and hormonal regulation of a-amylase gene expression. Plant Cell 14: 1963-1980.
  50. Chen PW, Lu CA, Yu TS, Tseng, TH, Wang CS, Yu SM (2002) Rice a-amylase transcriptional enhancers direct multiple mode regulation of promoters in transgenic rice. J Biol Chem 277: 13641-13649.
  51. Lu CA, Lim EK, Yu SM (1998) Sugar response sequence in the promoter of a rice a-amylase gene serves as transcriptional enhancer. J Biol Chem 273:10120-10131.
Teaching
  • Molecular Biology
  • Plant Tissue Culture
  • Plant signal transduction
  • Special Topics in Pant Hormone
Honors
  1. Best Research Paper Award for top journal publication at 2008 College of Science, National Central University
  2. “The SnRK1A Protein Kinase Plays a Key Role in Sugar Signaling during Germination and Seedling Growth of Rice” was recommended by Faculty of 1000 Biology in 2007 (as the first author of this Pant Cell paper).
Laboratory
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