Full-time Professors (Biomedicine)-Department of Life Sciences, NCU

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HOMEFacultyFull-time Professors (Biomedicine)Dr. Shih-Jung Fan

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Full-time Professors (Biomedicine)

  • Release: 2022-02-10
  • Update: 2025-08-18
  • Source：
  • Visits：5192

Dr. Shih-Jung Fan

  • Job title: Assistant Professor
  • Education: EMBL and University of Heidelberg
  • Expertise: Cell biology、microenvironmental nutrient sensing mechanism、oncology、molecular biology、 RNA biology
  • mailbox: sjfan@ncu.edu.tw
  • Extension: 65088
Introduction
  1. Position: Assistant Professor
  2. Education:
    1. Ph.D in Biology in the laboratory of Dr. Anne Ephrussi at the European Molecular Biology Laboratory (EMBL). Joint PhD awarded from the EMBL and University of Heidelberg.
    2. M.S. in Zoology in the laboratory of Dr. Tze-Bin Chou at the Institute of Zoology, National Taiwan University
    3. B.S. in Zoology in the Department of Zoology, National Taiwan University
  3. Professional Experience:
    1. 2021/08-present： Assistant Professor, Department of Life Sciences, National Central University
    2. 09/2001- 06/2002   Postgraduate Research Assistant in the laboratory of Prof. Tze-Bin Chou at the Institute of Zoology, National Taiwan University.
    3. 07/2004 - 07/2005   Postgraduate Research Assistant in the laboratory of Dr. Eminy Lee at the Institute of Biomedical Science, Academia Sinica, Taiwan
    4. 11/2009 - 04/2010   Short-term Postdoctoral Fellow in the laboratory of Dr. Anne Ephrussi at the EMBL, Heidelberg.
    5. 05/2010–05/2011   Postdoctoral Visiting Scientist in the laboratory of Dr. Anne Ephrussi at the EMBL, Heidelberg.
    6. 07/2011–07/2014   Postdoctoral Scientist funded by the Wellcome Trust in the laboratories of Prof. Clive Wilson and Prof. Deborah Goberdhan at the University of Oxford.
  4. Contact:886-3-422-7151 ext 65088
  5. FAX:(03) 422-8482
  6. E-mail: sjfan@ncu.edu.tw
Research

1. Exosome biology

2. Amino acid sensing of mTORC1 signalling

3. mRNA regulation

Paper
1. Singh PJ, Verma B, Wells A, Mendes CC, Dunn D, Chen YN, Oh J, Blincowe L, Wainwright SM, Fischer R, Fan SJ, Harris AL, Goberdhan DCI, Wilson C. (2025) Amyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes EMBO Journal. doi: 10.1038/s44318-025-00497-y. (5 Year IF=10.6, Ranking: 30/319 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
2. Mason J, Marks E, Fan SJ, McCormick K, Wilson C, Harris A, Hamdy F, Cunningham C, Goberdhan DC. (2024) Stress‐induced Rab11a‐exosomes induce amphiregulin‐mediated cetuximab resistance in colorectal cancer. Journal of Extracellular Vesicles. 13(6):e12465. (5 Year IF=16.7, Ranking: 15/204 in CELL BIOLOGY)
3. Marie P*, Fan SJ*, Mason J, Wells A, Mendes C, Wainwright M, Scott S, Fischer R, Harris A, Wilson C, Goberdhan DC. (2023) Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. Journal of Extracellular Vesicles. 12(3):e12311. (5 Year IF=16.7, Ranking: 15/204 in CELL BIOLOGY)
   *contributed equally to this paper
4. Wainwright M, Hopkins BR, Mendes CC, Sekar A, Kroeger B, Hellberg JEEU, Fan SJ, Pavey A, Marie P, Leiblich A, Sepil I, Charles PD, Thezenas ML, Fischer R, Kessler BM, Gandy C, Corrigan L, Patel R, Wigby S, Morrisa JF, Goberdhan DC, Wilson C (2021). Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid. Proceedings of the National Academy of Sciences. 118(5): e2019622118 (5 Year IF=10.6, Ranking: 14/135 in MULTIDISCIPLINARY SCIENCES)
5. Morotti M, Zois CE, El-Ansari R, Craze ML, Rakha EA, Fan SJ, Valli A, Haider S, Goberdhan DC, Green AR & Harris AL. (2021) Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. British Journal of Cancer. PMID: 33028955 DOI: 10.1038/s41416-020-01113-y (5 Year IF=8.6, Ranking: 47/326 in ONCOLOGY)
6. Fan SJ*, Kroeger B*, Marie P, Bridges E, Mason J, McCormick K, Zois C, Sheldon H, Alham NK, Johnson EL, Ellis M, Stefana I, Mendes CC, Wainwright M, Cunningham C, Hamdy F, Morris F, Harris A, Wilson C, Goberdhan DC. (2020) Glutamine Deprivation Regulates the Origin and Function of Cancer Cell Exosomes. EMBO Journal. 39:e103009. (5 Year IF=10.6, Ranking: 30/319 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
   *contributed equally to this paper
7. Fan SJ, Goberdhan DC (2018). PATs and SNATs: Amino Acid Sensors in Disguise. Frontiers in Pharmacology. 19;9:640 (5 Year IF=5.2, Ranking: 51/352 in PHARMACOLOGY & PHARMACY)
8. Fan SJ*, Snell C*, Turley H, Li JL, McCormick R, Perera SM, Heublein S, Kazi S, Azad A,Wilson C, Harris AL, Goberdhan DC (2016). PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. 35(23):3004-3015 (5 Year IF=7.4, Ranking: 39/319 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
   *contributed equally to this paper
9. Redhai S, Hellberg JE, Wainwright M, Perera SW, Castellanos F, Kroeger B, Gandy C, Leiblich A, Corrigan L, Hilton T, Patel B, Fan SJ, Hamdy F, Goberdhan DC, Wilson C. (2016) Regulation of dense-core granule replenishment by autocrine BMP signalling in Drosophila secondary cells. PLoS Genetics. 11;12(10):e1006366  (5 Year IF=4.5, Ranking: 31/191 in GENETICS & HEREDITY)
10. Mensah LB, Davison C, Fan SJ, Morris JF, Goberdhan DC, Wilson C (2015). Fine-tuning of PI3K/AKT signalling by the tumour suppressor PTEN is required for maintenance of flight muscle function and mitochondrial integrity in ageing adult Drosophila melanogaster. PloS One. 10(11):e0143818  (5 Year IF=3.2, Ranking: 44/135 in MULTIDISCIPLINARY SCIENCES)
11. Corrigan L, Redhai S, Leiblich A, Fan SJ, Perera SM, Patel R, Gandy C, Wainwright SM, Morris JF, Hamdy F, Goberdhan DC*, Wilson C* (2014). BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. Journal of Cell Biology. 206, 671-688. *contributed equally to this paper (5 Year IF=7.2, Ranking: 48/204 in CELL BIOLOGY)
12. Fan SJ, Marchand V, Ephrussi A (2011). Drosophila Ge-1 promotes P body formation and oskar mRNA localization. PLoS One. 6(5):e20612 (5 Year IF=3.2, Ranking: 44/135 in MULTIDISCIPLINARY SCIENCES)
13. Lin MD, Fan SJ, Hsu WS, Chou TB (2006). Drosophila decapping protein 1, dDcp1, is a component of the oskar mRNP complex and directs its posterior localization in the oocyte. Developmental Cell. 10(5):601-613. (5 Year IF=11.4, Ranking: 2/39 in DEVELOPMENTAL BIOLOGY)
14. Fan SR, Ho IC, Yeoh FL, Lin CJ, Lee TC (1996). Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. Mutation Research. 368(3-4):165-169 (5 Year IF=N.A., Ranking: 11/74 in TOXICOLOGY)
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