Full-time Professors (Biomedicine)-Department of Life Sciences, NCU

STAFFFaculty

HOMEFacultyFull-time Professors (Biomedicine)Dr. Shen-Liang Chen

Faculty

Full-time Professors (Biomedicine)

  • Release: 2022-02-10
  • Update: 2022-02-11
  • Source：
  • Visits：1741

Dr. Shen-Liang Chen

  • Job title: Distinguished Professor
  • Education: Department of Biochemistry, Institute for Molecular Bioscience, The University of Queensland, Australia
  • Expertise: Transcriptional Regulation, Gene Expression, Endocrinology, Molecular Biology
  • mailbox: slchen@cc.ncu.edu.tw
  • Extension: 65069
Introduction
  1. Position: Professor
  2. Education:  
    1. Department of Biochemistry, Institute for Molecular Bioscience, The University of Queensland, Australia
  3. Professional Experience:
    1. Professor, National Central University (Jung-li, Taiwan) (2016/8~present)
    2. Associate Professor, National Central University (Jung-li, Taiwan) (2010/8~2016/7)
    3. Assistant Professor, National Central University (Jung-li, Taiwan) (2003/8~2010/7)
  4. Current Position: 2016/8~present Professor
  5. Contact:886-3-422-7151 ext 65079
  6. FAX:(03) 422-8482
  7. E-mail:slchen@cc.ncu.edu.tw

Research
Transcriptional Regulation, Gene Expression, Endocrinology, Molecular Biology
Paper
  1. The cooperation of cis-elements during M-cadherin promoter activation. Lin YJ, Kao CH, Hsaio SP, Chen SL*. Biochem J. 2021 Feb 2:BCJ20200535. doi: 10.1042/BCJ20200535. Online ahead of print.
  2. Guo BC, Kuo KL, Chen CH, Chen SL, Tsou TC, Lee TS*. Di-(2-ethylhexyl) phthalate limits the pleiotropic effects of statins in chronic kidney disease patients undergoing dialysis and endothelial cells. Environ Pollut. 2020 Aug 28;267:115548. doi: 10.1016/j.envpol.2020.115548. Online ahead of print. (IF: 6.79)
  3. Hsu JW, Nien CY, Yeh SC, Tsai FY, Chen HW, Lee TS, Chen SL, Kao YH, Tsou TC*. Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo. Food Chem Toxicol. 2020 Aug;142:111487. doi: 10.1016/j.fct.2020.111487. Epub 2020 Jun 6. (IF: 4.679)
  4. Chen YH, Wu YJ, Chen WC, Lee TS, Tsou TC, Chang HC, Lo SW, Chen SL*. MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells. Biosci Rep. 2020 Apr 30;40(4). pii: BSR20194404. doi: 10.1042/BSR20194404. (IF: 2.9)
  5. Chang HC, Kao CH, Chung SY, Chen WC, Aninda LP, Chen YH, Juan YA, Chen SL*. Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells. Redox Biol. 2019 Jan; 20:321-333. doi: 10.1016/j.redox.2018.10.009. (IF: 9.98)
  6. Chi HC, Chen SL, Lin SL, Tsai CY, Chuang WY, Lin YH, Huang YH, Tsai MM, Yeh CT, Lin KH*. Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene. 2017 Sep 14;36(37):5274-5284. doi: 10.1038/onc.2017.136. Epub 2017 May 15. (IF: 7.97)
  7. Chi HC, Chen SL, Tsai CY, Chuang WY, Huang YH, Tsai MM, Wu SM, Sun CP, Yeh CT, Lin KH*. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016 Dec;12(12):2271-2285. Epub 2016 Sep 21.  (IF: 9.7)
  8. Chi HC, Chen SL, Cheng YH, Lin TK, Tsai CY, Tsai MM4, Lin YH, Huang YH, Lin KH*. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis. 2016 Aug 4; 7(8):e2324. doi: 10.1038/cddis.2016.227. (IF: 6.3)
  9. Lu TC, Zhao GH, Chen YY, Chien CY, Huang CH, Lin KH, Chen SL*. Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. J Cancer. 2016 Jun 28; 7(10):1360-73. doi: 10.7150/jca.15155. (IF: 3.6)
  10. Chung SC, Kao CH, Villarroya F, Chang HY, Chang HC, Hsiao SP, Liou GG, and Chen SL*. Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells. Mol Cell Biol. 2015 Jul 15; 35(14):2518-29. doi: 10.1128 (IF: 3.6)
  11. Pan YC, Wang XW, Teng HF, W YJ, Chang HC, and Chen SL*.  Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer. Biosci Rep. (2015) Mar 18; 35(2). pii: e00180, doi:10.1042/BSR20140177.  (IF: 2.9)
  12. Wu HJ, Fong TH, Chen SL, Wei JC, Wang IJ, Wen CC, Chang CY, Chen XG, Chen WY, Chen HM, Horng JL, Wang YH, Chen YH*. Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment. J Appl Toxicol. 2015 Mar;35(3):287-94. doi: 10.1002/jat.3057. (IF: 2.99)
  13. Wu SL, Li GZ, Chou CY, Tsai MS, Chen YP, Li CJ, Liou GG, Chang WW, Chen SL, Wang SH*. Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation. Cell Tissue Res. 2014 Aug 19. (IF: 4.0)
  14. Wu YJ, Fang YH, Chi HC, Chang LC, Chung SY, Huang WC, Wang XW, Lee KW, Chen SL*. Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts. PLoS ONE (2014) 9(2): e88450. doi:10.1371/journal.pone.0088450. (IF 2.7)
  15. Teng HF, Li PN, Hou DR, Liu SW, Lin CT, Loo MR, Kao CH, Lin KH, Chen SL*.  Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors. Mol Cell Endocrinol. 2014 Mar 5; 383(1-2):147-58. doi:10.1016/j.mce.2013.12.008.  (IF 3.87)
  16. Chung SY, Huang WC, Su CW, Lee KW, Chi HC, Lin CT, Chen ST, Huang KM, Tsai MS, Yu HP, Chen SL*.  FoxO6 and PGC-1α form a regulatory loop in myogenic cells. Biosci Rep. 2013 Jun 13; 33(3).  pii: e00045. doi: 10.1042/BSR20130031. (IF 2.9)
  17. Chi HC, Chen SL, Liao CJ, Liao CH, Tsai MM, Lin YH, Huang YH, Yeh CT, Wu SM, Tseng YH, Chen CY, Tsai CY, Chung IH, Chen WJ, Lin KH*. Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL. Cell Death Differ. 2012 Nov;19(11):1802-14. doi: 10.1038/cdd.2012.58 (IF: 10.7)
  18. Yang CC, Liu H, Chen SL, Wang TH, Hsieh CL, Huang Y, Chen SJ, Chen HC, Yung BY, Chin-Ming Tan B*. Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.  (IF: 6.79) EMBO J. 2012 Feb 14; 31 (7):1739-51. (IF 9.88)
  19. Wang SS, Lin MS, Chen SL, Chang Y, Ruaan RC, Chen WY* Using isothermal titration calorimetry to real-time monitor the heat of metabolism: a case study using PC12  cells and Aβ (1-40). Colloids Surf B Biointerfaces. 2011 Apr 1; 83 (2):307-12. (IF: 4.38)
  20. Teng HF, Kuo YL, Loo MR, Li CL, Chu TW, Suo H, Liu HS, Lin KH, Chen SL*. Valproic acid enhances Oct4 promoter activity in myogenic cells. Journal of Cellular Biochemistry 2010, 110 (4):995-1004. (IF 4.2)
  21. Hsiao SP and Chen SL*  Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements. Biochemical Journal 2010 June 1; 428: 223-233. (IF 4.09)
  22. Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F*. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. J Biol Chem. 2009 Aug 14; 284 (33):21872-80. (IF: 4.1)
  23. Lang KC, Lin IH, Teng HF, Huang YC, Li CL, Tang KT, and Chen SL*. Simultaneous over-expression of Oct4 and Nanog abrogates terminal myogenesis. Am J Physiol Cell Physiol. 2009 Jul; 297 (1):C43-54. (IF: 3.48)
  24. Hsiao SP, Huang KM, Chang HY, and Chen SL*. P/CAF rescues Bhlhe40-mediated repression of MyoD transactivation. Biochem J. 2009 Aug 13; 422 (2):343-52.  (IF: 4.09)
  25. Chen RN, Huang YH, Lin YC, Yeh CT, Liang Y, Chen SL, Lin KH*.  Thyroid hormone promotes cell invasion through activation of Furin expression in human hepatoma cell lines. Endocrinology. 2008 Aug; 149 (8):3817-31. (IF 4.7)
  26. Chang JH, Lin KH, Shih CH, Chang YH, Chi HC, and Chen SL*.  Myogenic Basic Helix loop helix proteins regulate the expression of peroxisomal proliferator activated receptor-γ coactivator 1α. Endocrinology 2006 Jun 147 (6): 3093-3106. (IF: 3.93)
  27. Lin KH*, Chen CY, Chen SL, Yen CC, Huang YH, Shih CH, Shen JJ, Yang RC, and Wang CS.  Regulation of Fibronectin by thyroid hormone receptors. J Mol Endocrinol. 2004 Oct; 33 (2):445-58.. (IF: 3.56)
  28. Wang CS, Lin KH*, Chen SL, Chan YF, Hsueh S. Over-expression of SPARC gene in Human Gastric Carcinoma and its Clinic-pathological Significance. Br J Cancer. 2004 Nov 29; 91 (11):1924-30. (IF: 5.79
  29. Shih CH, Chen SL, Yen CC, Huang YH, Chen CD, Lee YS, Lin KH*. Thyroid Hormone Receptor Dependent Transcriptional Regulation of Fibrinogen and Coagulation Proteins. Endocrinology. 2004 Jun; 145 (6):2804-14  (IF: 3.93)
  30. Lin KH*, Lee HY, Shih GC, Yen CC, Chen SL, Yang YC, Wang CS. Plasma protein regulation by thyroid hormone. J Endocrinol. 2003 Dec; 179 (3):367-377.  (IF: 4.0)
  31. Chen SL, Wu YS, Shieh HY, Yen CC, Shen JJ, Lin KH*. P53 is a regulator of the metastasis suppressor gene Nm23-H1. Mol Carcinog. 2003 Apr; 36 (4):204-14.  (IF: 3.8)
  32. Chen SL, Chang YJ, Wu YH, and Lin KH*. Mitogen-activated protein kinases potentiate thyroid hormone receptor transcriptional activity by stabilizing its protein. Endocrinology 2003 Apr; 144 (4):1407-19.  (IF: 3.93)
  33. Harris JM, Lau P, Chen SL, and Muscat GEO*. Characterization of the RORα coactivator binding interface: A structural basis for ligand independent transcription. Molecular Endocrinology 2002 May; 16 (5):998-1012.  (IF: 3.62)
  34. Chen SL, Loffler KA, Chen D, Michael R. Stallcup MR, and Muscat GE*. The Coactivator Associated Arginine Methyltransferase Is necessary for muscle differentiation: CARM1 functions as a secondary coactivator for MEF2. J Biol Chem. 2002 Feb. 8; 277(6): 4324-4333.  (IF: 4.1)
  35. Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat G*.  SOX18 directly interacts with MEF2Cin endothelial cells. Biochem Biophys Res Commun. 2001 Sep 21; 287 (2):493-500.  (IF: 2.98)
  36. Chen SL, Wang SC, Hosking B, Muscat GE*. Subcellular localization of the steroid receptor coactivators (SRCs) and MEF2 inmuscle and rhabdomyosarcoma cells. Mol Endocrinol. 2001 May; 15 (5):783-96.  (IF: 3.62)
  37. Chen SL, Dowhan DH, Hosking BM, Muscat GE*. The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev. 2000 May 15; 14 (10):1209-28. (IF:9.52)
  38. Lin KH*, Wu YH, Chen SL.Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators. Endocrinology. 2001 Feb; 142 (2):653-62.  (IF: 3.93)
  39. Bailey P, Downes M, Lau P, Harris J, Chen SL, Hamamori Y, Sartorelli V, Muscat GE*. The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD. Mol Endocrinol. 1999 Jul; 13 (7):1155-68.  (IF: 3.62)
  40. Lin KH*, Shieh HY, Chen SL, Hsu HC. Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells. Mol Carcinog. 1999 Sep; 26 (1):53-61.  (IF: 3.92)
  41. Lin KH, Zhu XG, Hsu HC, Chen SL, Shieh HY, Chen ST, McPhie P, Cheng SY*. Dominant negative activity of mutant thyroid hormone alpha1 receptors from patients with hepatocellular carcinoma. Endocrinology. 1997 Dec; 138 (12):5308-15.  (IF: 3.93)
  42. Lin KH, Chen SL, Zhu XG, Shieh HY, McPhie P, Cheng SY* The gene regulating activity of thyroid hormone nuclear receptors is modulated by cell-type specific factors. Biochem Biophys Res Commun. 1997 Sep 18; 238 (2):280-4.  (IF: 2.98)
Teaching
  1. Developmental biology
  2. Gene Regulation
  3. Molecular cell biology
  4. Biochemistry
  5. Ocean Biology
  6. Genetics
  7. Cell biology
Society
Laboratory
BACK