專任教授(生物醫學組)-中央大學生命科學系資訊網

STAFF系所成員

首頁系所成員專任教授(生物醫學組)陳盛良 博士

系所成員

專任教授(生物醫學組)

  • 發佈日期: 2019-08-28
  • 最後更新日: 2024-04-22
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陳盛良 博士

  • 職稱: 特聘教授
  • 學歷: 澳洲昆士蘭大學
  • 專長: 基因調控、基因表達、內分泌、分子生物學
  • 信箱: slchen@cc.ncu.edu.tw
  • 分機: 65069、65079
現職與學經歷
  • 現  職：
  1. 國立中央大學 生命科學系 特聘教授 (2019~present)
  2. 國立中央大學 生命科學系 教授 (2016~present)
  • 學  歷：
  1. 澳洲昆士蘭大學 (博士)
  2. 國立台灣大學海洋研究所 (碩士)
  3. 國立台灣海洋大學漁業科學系 (學士)
  • 經  歷：
  1. 國立中央大學 生命科學系 特聘教授 (2019~present)
  2. 國立中央大學 生命科學系 教授 (2016~present)
  3. 國立中央大學 生命科學系 副教授 (2010~2016)
  4. 國立中央大學 生命科學系 助理教授 (2003~2010)
  5. 長庚大學 醫學院生化科 博士後研究員 (2002~2003)
  6. 長庚大學 醫學院生化科 研究助理 (1995~1998)
  7. 中央研究院 動物研究所 研究助理 (1994~1995)
授課與研究領域
  • 授  課
  1. 發育生物學
  2. 細胞分化
  3. 腫瘤生物學
  4. 基因調控
  5. 分子細胞生物學
  6. 生物化學
  7. 海洋生物學
  8. 無脊椎動物學
  9. 遺傳學
  10. 細胞生物學
  • 研究領域
    細胞分化的基因調控

    多細胞生物的最大特點是在於細胞間的分工合作。不同的細胞，職司不同的專業工作，例如：消化細胞－分泌消化酵素；神經細胞－傳道電流訊號等。如果沒有細胞間的分工合作 ，那麼每一個細胞就必須要同時能執行這些所有的工作，所造成的結果，將是有如一個建築師要同時擔任水泥工與水電工的工作，工作的細緻程度，將大大的減低。

    細胞分化的過程主要發生再胚胎發育的時期，單細胞的授精卵，在卵內的不同區域，儲存了不同的調控因子的蛋白質或mRNA這些調控因子在緊接而來的快速卵裂過程中分配至不同的子細胞中 ，因此使他們產生初步的分化，這些細胞間，這些細胞間可以進行彼此間的交談與對話，並且告訴對方，去進行下一步的分化，細胞於是就是這樣的一步一步的走向最終的分化路徑 。

    　　 本實驗室的工作專注於了解前驅細胞－幹細胞走向，可執行特定工作的終極分化細胞的過程中，轉錄調控因子，對細胞品係決定基因以及分化後的功能基因上啟動子 ，或其他調控單元的調控機制的分析。目前已建立的研究平台有肌肉細胞的分化系統以及胚胎癌幹細胞的品系決定系統。




論文發表

論  文     


  1. The cooperation of cis-elements during M-cadherin promoter activation. Lin YJ, Kao CH, Hsaio SP, Chen SL*. Biochem J. 2021 Feb 2:BCJ20200535. doi: 10.1042/BCJ20200535. Online ahead of print.
  2. Guo BC, Kuo KL, Chen CH, Chen SL, Tsou TC, Lee TS*. Di-(2-ethylhexyl) phthalate limits the pleiotropic effects of statins in chronic kidney disease patients undergoing dialysis and endothelial cells. Environ Pollut. 2020 Aug 28;267:115548. doi: 10.1016/j.envpol.2020.115548. Online ahead of print. (IF: 6.79)
  3. Hsu JW, Nien CY, Yeh SC, Tsai FY, Chen HW, Lee TS, Chen SL, Kao YH, Tsou TC*. Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo. Food Chem Toxicol. 2020 Aug;142:111487. doi: 10.1016/j.fct.2020.111487. Epub 2020 Jun 6. (IF: 4.679)
  4. Chen YH, Wu YJ, Chen WC, Lee TS, Tsou TC, Chang HC, Lo SW, Chen SL*. MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells. Biosci Rep. 2020 Apr 30;40(4). pii: BSR20194404. doi: 10.1042/BSR20194404. (IF: 2.9)
  5. Chang HC, Kao CH, Chung SY, Chen WC, Aninda LP, Chen YH, Juan YA, Chen SL*. Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells. Redox Biol. 2019 Jan; 20:321-333. doi: 10.1016/j.redox.2018.10.009. (IF: 9.98)
  6. Chi HC, Chen SL, Lin SL, Tsai CY, Chuang WY, Lin YH, Huang YH, Tsai MM, Yeh CT, Lin KH*. Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene. 2017 Sep 14;36(37):5274-5284. doi: 10.1038/onc.2017.136. Epub 2017 May 15. (IF: 7.97)
  7. Chi HC, Chen SL, Tsai CY, Chuang WY, Huang YH, Tsai MM, Wu SM, Sun CP, Yeh CT, Lin KH*. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016 Dec;12(12):2271-2285. Epub 2016 Sep 21.  (IF: 9.7)
  8. Chi HC, Chen SL, Cheng YH, Lin TK, Tsai CY, Tsai MM4, Lin YH, Huang YH, Lin KH*. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis. 2016 Aug 4; 7(8):e2324. doi: 10.1038/cddis.2016.227. (IF: 6.3)
  9. Lu TC, Zhao GH, Chen YY, Chien CY, Huang CH, Lin KH, Chen SL*. Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. J Cancer. 2016 Jun 28; 7(10):1360-73. doi: 10.7150/jca.15155. (IF: 3.6)
  10. Chung SC, Kao CH, Villarroya F, Chang HY, Chang HC, Hsiao SP, Liou GG, and Chen SL*. Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells. Mol Cell Biol. 2015 Jul 15; 35(14):2518-29. doi: 10.1128 (IF: 3.6)
  11. Pan YC, Wang XW, Teng HF, W YJ, Chang HC, and Chen SL*.  Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer. Biosci Rep. (2015) Mar 18; 35(2). pii: e00180, doi:10.1042/BSR20140177.  (IF: 2.9)
  12. Wu HJ, Fong TH, Chen SL, Wei JC, Wang IJ, Wen CC, Chang CY, Chen XG, Chen WY, Chen HM, Horng JL, Wang YH, Chen YH*. Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment. J Appl Toxicol. 2015 Mar;35(3):287-94. doi: 10.1002/jat.3057. (IF: 2.99)
  13. Wu SL, Li GZ, Chou CY, Tsai MS, Chen YP, Li CJ, Liou GG, Chang WW, Chen SL, Wang SH*. Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation. Cell Tissue Res. 2014 Aug 19. (IF: 4.0)
  14. Wu YJ, Fang YH, Chi HC, Chang LC, Chung SY, Huang WC, Wang XW, Lee KW, Chen SL*. Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts. PLoS ONE (2014) 9(2): e88450. doi:10.1371/journal.pone.0088450. (IF 2.7)
  15. Teng HF, Li PN, Hou DR, Liu SW, Lin CT, Loo MR, Kao CH, Lin KH, Chen SL*.  Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors. Mol Cell Endocrinol. 2014 Mar 5; 383(1-2):147-58. doi:10.1016/j.mce.2013.12.008.  (IF 3.87)
  16. Chung SY, Huang WC, Su CW, Lee KW, Chi HC, Lin CT, Chen ST, Huang KM, Tsai MS, Yu HP, Chen SL*.  FoxO6 and PGC-1α form a regulatory loop in myogenic cells. Biosci Rep. 2013 Jun 13; 33(3).  pii: e00045. doi: 10.1042/BSR20130031. (IF 2.9)
  17. Chi HC, Chen SL, Liao CJ, Liao CH, Tsai MM, Lin YH, Huang YH, Yeh CT, Wu SM, Tseng YH, Chen CY, Tsai CY, Chung IH, Chen WJ, Lin KH*. Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL. Cell Death Differ. 2012 Nov;19(11):1802-14. doi: 10.1038/cdd.2012.58 (IF: 10.7)
  18. Yang CC, Liu H, Chen SL, Wang TH, Hsieh CL, Huang Y, Chen SJ, Chen HC, Yung BY, Chin-Ming Tan B*. Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.  (IF: 6.79) EMBO J. 2012 Feb 14; 31 (7):1739-51. (IF 9.88)
  19. Wang SS, Lin MS, Chen SL, Chang Y, Ruaan RC, Chen WY* Using isothermal titration calorimetry to real-time monitor the heat of metabolism: a case study using PC12  cells and Aβ (1-40). Colloids Surf B Biointerfaces. 2011 Apr 1; 83 (2):307-12. (IF: 4.38)
  20. Teng HF, Kuo YL, Loo MR, Li CL, Chu TW, Suo H, Liu HS, Lin KH, Chen SL*. Valproic acid enhances Oct4 promoter activity in myogenic cells. Journal of Cellular Biochemistry 2010, 110 (4):995-1004. (IF 4.2)
  21. Hsiao SP and Chen SL*  Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements. Biochemical Journal 2010 June 1; 428: 223-233. (IF 4.09)
  22. Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F*. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. J Biol Chem. 2009 Aug 14; 284 (33):21872-80. (IF: 4.1)
  23. Lang KC, Lin IH, Teng HF, Huang YC, Li CL, Tang KT, and Chen SL*. Simultaneous over-expression of Oct4 and Nanog abrogates terminal myogenesis. Am J Physiol Cell Physiol. 2009 Jul; 297 (1):C43-54. (IF: 3.48)
  24. Hsiao SP, Huang KM, Chang HY, and Chen SL*. P/CAF rescues Bhlhe40-mediated repression of MyoD transactivation. Biochem J. 2009 Aug 13; 422 (2):343-52.  (IF: 4.09)
  25. Chen RN, Huang YH, Lin YC, Yeh CT, Liang Y, Chen SL, Lin KH*.  Thyroid hormone promotes cell invasion through activation of Furin expression in human hepatoma cell lines. Endocrinology. 2008 Aug; 149 (8):3817-31. (IF 4.7)
  26. Chang JH, Lin KH, Shih CH, Chang YH, Chi HC, and Chen SL*.  Myogenic Basic Helix loop helix proteins regulate the expression of peroxisomal proliferator activated receptor-γ coactivator 1α. Endocrinology 2006 Jun 147 (6): 3093-3106. (IF: 3.93)
  27. Lin KH*, Chen CY, Chen SL, Yen CC, Huang YH, Shih CH, Shen JJ, Yang RC, and Wang CS.  Regulation of Fibronectin by thyroid hormone receptors. J Mol Endocrinol. 2004 Oct; 33 (2):445-58.. (IF: 3.56)
  28. Wang CS, Lin KH*, Chen SL, Chan YF, Hsueh S. Over-expression of SPARC gene in Human Gastric Carcinoma and its Clinic-pathological Significance. Br J Cancer. 2004 Nov 29; 91 (11):1924-30. (IF: 5.79
  29. Shih CH, Chen SL, Yen CC, Huang YH, Chen CD, Lee YS, Lin KH*. Thyroid Hormone Receptor Dependent Transcriptional Regulation of Fibrinogen and Coagulation Proteins. Endocrinology. 2004 Jun; 145 (6):2804-14  (IF: 3.93)
  30. Lin KH*, Lee HY, Shih GC, Yen CC, Chen SL, Yang YC, Wang CS. Plasma protein regulation by thyroid hormone. J Endocrinol. 2003 Dec; 179 (3):367-377.  (IF: 4.0)
  31. Chen SL, Wu YS, Shieh HY, Yen CC, Shen JJ, Lin KH*. P53 is a regulator of the metastasis suppressor gene Nm23-H1. Mol Carcinog. 2003 Apr; 36 (4):204-14.  (IF: 3.8)
  32. Chen SL, Chang YJ, Wu YH, and Lin KH*. Mitogen-activated protein kinases potentiate thyroid hormone receptor transcriptional activity by stabilizing its protein. Endocrinology 2003 Apr; 144 (4):1407-19.  (IF: 3.93)
  33. Harris JM, Lau P, Chen SL, and Muscat GEO*. Characterization of the RORα coactivator binding interface: A structural basis for ligand independent transcription. Molecular Endocrinology 2002 May; 16 (5):998-1012.  (IF: 3.62)
  34. Chen SL, Loffler KA, Chen D, Michael R. Stallcup MR, and Muscat GE*. The Coactivator Associated Arginine Methyltransferase Is necessary for muscle differentiation: CARM1 functions as a secondary coactivator for MEF2. J Biol Chem. 2002 Feb. 8; 277(6): 4324-4333.  (IF: 4.1)
  35. Hosking BM, Wang SC, Chen SL, Penning S, Koopman P, Muscat G*.  SOX18 directly interacts with MEF2Cin endothelial cells. Biochem Biophys Res Commun. 2001 Sep 21; 287 (2):493-500.  (IF: 2.98)
  36. Chen SL, Wang SC, Hosking B, Muscat GE*. Subcellular localization of the steroid receptor coactivators (SRCs) and MEF2 inmuscle and rhabdomyosarcoma cells. Mol Endocrinol. 2001 May; 15 (5):783-96.  (IF: 3.62)
  37. Chen SL, Dowhan DH, Hosking BM, Muscat GE*. The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev. 2000 May 15; 14 (10):1209-28. (IF:9.52)
  38. Lin KH*, Wu YH, Chen SL.Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators. Endocrinology. 2001 Feb; 142 (2):653-62.  (IF: 3.93)
  39. Bailey P, Downes M, Lau P, Harris J, Chen SL, Hamamori Y, Sartorelli V, Muscat GE*. The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD. Mol Endocrinol. 1999 Jul; 13 (7):1155-68.  (IF: 3.62)
  40. Lin KH*, Shieh HY, Chen SL, Hsu HC. Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells. Mol Carcinog. 1999 Sep; 26 (1):53-61.  (IF: 3.92)
  41. Lin KH, Zhu XG, Hsu HC, Chen SL, Shieh HY, Chen ST, McPhie P, Cheng SY*. Dominant negative activity of mutant thyroid hormone alpha1 receptors from patients with hepatocellular carcinoma. Endocrinology. 1997 Dec; 138 (12):5308-15.  (IF: 3.93)
  42. Lin KH, Chen SL, Zhu XG, Shieh HY, McPhie P, Cheng SY* The gene regulating activity of thyroid hormone nuclear receptors is modulated by cell-type specific factors. Biochem Biophys Res Commun. 1997 Sep 18; 238 (2):280-4.  (IF: 2.98)


榮譽事項
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實驗室成員


  • 碩士班學生：李寧

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